| 丝胶对2型糖尿病大鼠脊髓前角神经元NGF表达的影响 |
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| 引用本文： | 钟美蓉,付文亮,付秀美,马洪伟,陈志宏,薛景风. 丝胶对2型糖尿病大鼠脊髓前角神经元NGF表达的影响[J]. 承德医学院学报, 2010, 27(1): 5-8. DOI: 10.3969/j.issn.1004-6879.2010.01.003 |
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| 作者姓名： | 钟美蓉 付文亮 付秀美 马洪伟 陈志宏 薛景风 |
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| 作者单位： | 承德医学院,河北承德,067000;承德医学院,河北承德,067000;承德医学院,河北承德,067000;承德医学院,河北承德,067000;承德医学院,河北承德,067000;承德医学院,河北承德,067000 |
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| 摘 要： | 目的：研究丝胶对2型糖尿病大鼠脊髓前角神经元神经生长因子（Nerve growth factor，NGF）表达的影响。方法：40只SD大鼠随机分为4组，正常对照组、糖尿病模型组、丝胶治疗组和阳性对照组，每组均为10只。链脲佐菌素（Streptozotocin，STZ）连续腹腔注射制作2型糖尿病大鼠模型。待模型成功建立后，模型组大鼠不作任何处理，丝胶治疗组大鼠给予丝胶灌胃（2．4g／kg／d），阳性对照组大鼠给予二甲双胍（55．33mg／kg／d）灌胃。应用免疫组织化学染色法观察脊髓前角神经元NGF的表达，并采用MiVnt图像分析系统对免疫组化染色阳性结果进行定量分析。结果：糖尿病模型组大鼠脊髓前角神经元NGF的表达明显低于正常对照大鼠（P〈0．01）；与糖尿病模型组大鼠比较，丝胶治疗组与阳性对照组大鼠脊髓前角神经元NGF的表达明显增高（P〈0．01），且丝胶组与阳性对照组比较无明显差别（P〉0．05）。结论：丝胶可明显提高2型糖尿病大鼠脊髓前角神经元NGF的表达，发挥对糖尿病神经病变的保护作用。
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| 关 键 词： | 丝胶 神经生长因子 糖尿病 脊髓 前角神经元 |
EFFECTS OF SERICINE ON NGF EXPRESSION IN ANTERIOR HORNNEURONS OF TYPE 2 DIABETES MELLITUS RATS MODEL SPINAL CORD |
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| ZHONG Mei-rong,FU Wen-liang,FU Xiu-mei,et al. EFFECTS OF SERICINE ON NGF EXPRESSION IN ANTERIOR HORNNEURONS OF TYPE 2 DIABETES MELLITUS RATS MODEL SPINAL CORD[J]. Journal of Chengde Medical College, 2010, 27(1): 5-8. DOI: 10.3969/j.issn.1004-6879.2010.01.003 |
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| Authors: | ZHONG Mei-rong FU Wen-liang FU Xiu-mei et al |
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| Affiliation: | Chengde Medical College;Hebei Chengde 067000;China |
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| Abstract: | Objective:To study the effects of sericine on nerve growth factor (NGF) expression of anterior horn neurons in spinal cord of diabetic rats.Methods:40 SD rats were randomly divided into 4 groups (n=10):normal control group,diabetes model group,sericine treatment group and positive control group.The type 2 diabetes model rats were established by continuous intraperitoneal injection of Streptozotocin (STZ).After successfully establishing the diabetes rats model,The rats in diabetes model group were not given ... |
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| Keywords: | Sericine NGF Diabetes Spinal cord Anterior horn neurons |
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