Relation of locus 1p13 rs646776 polymorphism with the risk of preeclampsia |
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| Authors: | Rana H. Emam Maivel H. Ghattas Noha M. Mesbah Dina M. Abo-Elmatty |
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| Affiliation: | 1. Faculty of Pharmacy, Department of Biochmistry, Suez Canal University, Ismailia, Egypt;2. Faculty of Medicine, Department of Medical Biochemistry, Port Said University, Port Said, Egypt |
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| Abstract: | Objective: This study aimed to assess the relation of locus 1p13 rs646776 (T/C) polymorphism with preeclampsia in Egyptian women. Methods: The study included 100 healthy pregnant female subjects and 100 preeclampsia patients. The genotypes of the polymorphisms were assessed. Endothelin-1 level was determined in plasma. Results: The major T allele of the 1p13.3 genomic region rs646776 polymorphism had a higher frequency in preeclampsia patients. Carriers of C allele had significantly lower endothelin-1 levels, lower systolic and diastolic blood pressure, decreased proteinuria, and increased HDL-C in the patients. Conclusion: The rare C allele of rs646776 polymorphism in chromosomal locus 1p13.3 is associated with decreased risk of preeclampsia. |
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| Keywords: | Endothelin-1 preeclampsia rs646776 |
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