| NEW ANTIMICROBIAL SENSITIVITY TESTS OF BIOFILM OF STREPTOCOCCUS MUTANS IN ARTIFICIAL MOUTH MODEL |
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| 引用本文： | 李鸣宇 汪俊 刘正 朱彩莲. NEW ANTIMICROBIAL SENSITIVITY TESTS OF BIOFILM OF STREPTOCOCCUS MUTANS IN ARTIFICIAL MOUTH MODEL[J]. 上海第二医科大学学报, 2004, 16(2): 88-91 |
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| 作者姓名： | 李鸣宇 汪俊 刘正 朱彩莲 |
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| 作者单位： | [1]ShanghaiResearchInstituteofStomatology,theNinthPeople＇sHospital,SSMU,Shanghai200011,China [2]ShanghaiResearchInstituteofStomatology,theNinthPeople＇sHospital,SSMU,Shanghai200011,China |
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| 摘 要： | To develop a new antimicrobial sensitivity test model for oral products in vitro.Methods A biofllm artificial mouth model for antimicrobial sensitivity tests was established by modifying the LKB chromatography chamber. Using sodium fluoride and Tea polyphenol as antimicrobial agent and Streptococcus mutans as target, sensitivity tests were studied. Results The modeling biofilm assay resulted in a MIC of l. 28mg/ml for fluoride against S. mutans, which was 32 times the MlC for broth maco-dilution method. The differential resistance of bacteria bioflim to antimicrobial agent relative to planktonic cells was also demonstrated. Conclusion The biofilm artificial mouth model may be useful in oral products test.
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| 关 键 词： | 杀菌剂 灵敏性测试 生物薄膜 突变异种 链球菌 人造嘴模型 |
NEW ANTIMICROBIAL SENSITIVITY TESTS OF BIOFILM OF STREPTOCOCCUS MUTANS IN ARTIFICIAL MOUTH MODEL |
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| LI Ming-yu WANG Jun LIU Zheng,ZHU Cai-lianShanghai Research Institute of Stomatology,the Ninth People' s Hospital,SSMU,Shanghai ,China. NEW ANTIMICROBIAL SENSITIVITY TESTS OF BIOFILM OF STREPTOCOCCUS MUTANS IN ARTIFICIAL MOUTH MODEL[J]. Journal of Shanghai Second Medical University(Foreign Language Edition), 2004, 16(2): 88-91 |
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| Authors: | LI Ming-yu WANG Jun LIU Zheng ZHU Cai-lianShanghai Research Institute of Stomatology the Ninth People' s Hospital SSMU Shanghai China |
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| Affiliation: | LI Ming-yu WANG Jun LIU Zheng,ZHU Cai-lianShanghai Research Institute of Stomatology,the Ninth People' s Hospital,SSMU,Shanghai 200011,China |
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| Abstract: | Objective To develop a new antimicrobial sensitivity test model for oral products in vitro.Methods A biofilm artificial mouth model for antimicrobial sensitivity tests was established by modifying the LKB chromatography chamber. Using sodium fluoride and Tea polyphenol as antimicrobial agent and Streptococcus mu-tans as target, sensitivity tests were studied. Results The modeling biofilm assay resulted in a MIC of 1. 28mg/ ml for fluoride against S. mutans, which was 32 times the MIC for broth maco-dilution method. The differential resistance of bacteria bioflim to antimicrobial agent relative to planktonic cells was also demonstrated. Conclusion The biofilm artificial mouth model may be useful in oral products test. |
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| Keywords: | biofilm artificial mouth model antimicrobial sensitivity tests |
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