炮制与超微粉碎对水蛭药效影响的初步实验研究

目的 :比较水蛭煎剂、普通散剂的药效以及新法炮制与超微粉碎对其药效的影响。方法 :用BT-1500型离心沉降式粒度分布仪测定了生、制水蛭超微散的粒度。通过小鼠抗凝血、抗血栓作用 ,比较了水蛭丝水煎剂、1/2煎剂剂量的普通散、超微散、制水蛭超微散的药效。并对其安全性进行了考察。结果 :供试品药效由强到弱为制水蛭超微散、生水蛭超微散、生水蛭散、生水蛭水煎剂、对照组。结论 :水蛭经超微粉碎 ,尤其是新法炮制后超微粉碎 ,可明显改善气味、口感 ,提高药效。

Preliminary studies on Process and Ultramicro-pulverization on pharmacodynamics of Leech

Objective:To compare pharmacodynamics of decoction and powder of Leech;To identify effect of pharmacodynamics of Leech with new methods of process and ultrmicro-pulverization.Method:The size of ultramicor-powder of Leech and new method processed Leech is determined by BT-1500 size distributive instrument. It is compared that the pharmacodynamics of Leech decoction and powder as well as ultramicro-powder with new method processed of 1/2 decoction dose by anticoagulation and antithrombus action of mice. The safety of different samples is identified. Result:The pharmacodynamics of samples is as ultramicro-powder of Leech with new method processed>ultrmicro-powder of Leech>powder of Leech>decoction of Leech. Conclusion:The ultramicro-powder of Leech with new method processed has better pharmacodynamic effect and the smell of Leech is improved.