ER、PR 及 C-erbB-2、p53 在 87 例甲状腺癌中的表达及临床意义

目的：检测甲状腺癌中ER、PR及C—erbB-2，r63的表达并探讨它们的临床意义。方法：应用免疫组化S—P法对87例甲状腺癌、20例腺瘤、20例瘤旁甲状腺组织进行ER、PR、C—erbB-2、p53的检测。结果：甲状腺癌中ER、PR的阳性表达率分别为64．4％和63．2％，均与细胞分化程度，组织学类型有关，但与年龄，性别无关。无淋巴结转移组的甲状腺癌ER、PR阳性率为75．4％和70．5％，显著高于有转移组的53．8％和46．2％（P〈0．05）。C—erbB-2表达随癌组织分化程度增高而增高，p53表达随癌组织分化程度增高而减少，与C—erbB-2间呈负相关。在淋巴结转移组中C—erbB-2阳性率增高明显（P〈0．01）。结论：ER，PR，C—erbB-2，p53可作为甲状腺癌分化及恶性程度的评价指标，并且能反映预后。

Expression and clinical significance of ER,PR,C-erbB-2 and p53 in 87 cases of thyroid carcinoma

Objective:To study the expression of the estrogen receptor(ER),progesterone receptor(PR),C-erbB-2,p53 in thyroid carcinoma and their clinical significance.Methods:ER,PR,C-erbB-2,p53 in 87 cases of thyroid carcinoma,20 cases of adinoma and 20 cases of adjacent normal tissues of thyroid tumor were exmined using the method of immunohistochemistry S-P.Results:The positive rates of ER and PR were 64.4% and 63.2% respectively in thyroid carcinomas,which correlated with differentiation and histologic types,however did not relate to age and sex.The positive rates of ER and PR in the nonmetastatic group were 75.4% and 70.5%,significantly higher than those of the metastastatic group which were 53.8% and 46.2%(P<0.05).The expression of C-erbB-2 was increased with increasing of differentiation of the carcinoma.The expression of p53 was decreased with the increasing degree of differentiation.A significant inverse correlation was found beteen p53 and c-erbB-2.The positive rate of C-erbB-2 was obviously higher in the metastastatic cases(P<0.01).Conclusion:The expression of ER,PR,C-erbB-2 and p53 were related to tumor differentiation and the degree of malignancy and may indicate a poor prognosis.