| 不同年龄患者腹腔镜手术靶控输注罗库溴铵的药效学研究 |
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| 引用本文： | 王慧玲,杨拔贤,张利萍. 不同年龄患者腹腔镜手术靶控输注罗库溴铵的药效学研究[J]. 中国微创外科杂志, 2008, 8(4): 342-344 |
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| 作者姓名： | 王慧玲 杨拔贤 张利萍 |
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| 作者单位： | [1]北京大学人民医院麻醉科; [2]北京大学第三医院麻醉科; [3]北京 |
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| 摘 要： | 目的探讨不同年龄患者腹腔镜手术罗库溴铵靶控输注的靶浓度和药效学特点。方法31例择期腹腔镜下行普外科和妇科手术患者,根据病人年龄分为2组:老年组(年龄65～81岁,n=17)和青壮年组(年龄18～55岁,n=14)。全麻后靶控输注罗库溴铵,未给药侧上肢用TOF行肌松监测。初始靶浓度设定在1.0μg/ml,并根据肌松监测逐渐递增靶浓度,最终靶浓度选择以维持T1最大阻滞在90%～95%。记录每一个靶浓度对应的T1值和停止靶控输注后T1恢复至25%的时间,恢复指数和TOFR(四个成串刺激比率)恢复至0.7的时间作为药效学监测指标,并记录罗库溴铵的总平均输注速度。结果各靶浓度所至的T1值,老年组明显低于青壮年组(P<0.05),维持T1阻滞在90%～95%所需的靶浓度,老年组为2.2μg/ml,青壮年组为2.8μg/ml。老年组靶控输注罗库溴铵的平均速度和给药量为(7.9±1.7)μg/(kg.min)和(0.55±0.10)mg/min,明显小于青壮年组(9.8±1.2)μg/(kg.min)和(0.64±0.12)mg/min(t=-3.518和-2.279,P=0.001和0.030)。2组肌松恢复时间除恢复指数...
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| 关 键 词： | 罗库溴铵 靶控输注 药效学 年龄 腹腔镜手术 |
| 文章编号： | 1009-6604(2008)04-0342-03 |
| 修稿时间： | 2008-01-07 |
Pharmacodynamics of Rocuronium by Target-Controlled Infusion in Elderly and Adult Patients during Laparoscopy Operation |
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| Wang Huiling,Yang Baxian,Zhang Liping. Pharmacodynamics of Rocuronium by Target-Controlled Infusion in Elderly and Adult Patients during Laparoscopy Operation[J]. Chinese Journal of Minimally Invasive Surgery, 2008, 8(4): 342-344 |
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| Authors: | Wang Huiling Yang Baxian Zhang Liping |
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| Affiliation: | Wang Huiling; Yang Baxian; Zhang Liping.Department of Anesthesiology; Peking University People s Hospital; Beijing 100044; China; |
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| Abstract: | Objective To investigate the pharmacodynamics of rocuronium by targeted-controlled infusion(TCI)during laparoscopy in elderly and adult patients.Methods A total of 31 patients undergoing selective laparoscopy operation from the Department of Gynecology and Department of General Surgery were divided into elderly group(aged 65-81 years,n=17)and adults group(aged 18-55 years,n=14).Under general anesthesia,rocuronium was infused intravenously using a TCI system.The upper limb without intravenous infusion was em... |
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| Keywords: | Rocuronium Target-controlled infusion Pharmacodynamics Age Laparoscopy |
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