Runx3和Ki-67蛋白在皮肤恶性黑色素瘤中的表达

目的：检测Runx3和Ki-67蛋白在皮肤恶性黑色素瘤（CMM）中的表达水平,以探讨Runx3和Ki-67在CMM发生、发展过程中的作用。方法：采用免疫组织化学法研究Runx3和Ki-67蛋白在皮肤恶性黑色素瘤、皮肤交界痣及正常皮肤中的表达。结果：Runx3蛋白在CMM中阳性表达率为23.68%,与皮肤交界痣（85.00%）和正常皮肤（90.00%）相比,差异具有统计学意义（P〈0.05）;Ki-67蛋白在CMM中阳性表达率为78.95%,与皮肤交界痣（25.00%）和正常皮肤（25.00%）相比差异具有统计学意义（P〈0.05）。结论：皮肤恶性黑色素瘤的产生可能与Runx3蛋白的表达降低及Ki-67蛋白的表达升高有关。

Expression of Runx3 and Ki-67 in Cutaneous Malignant Melanoma

Objective To detect the expression of Runx3 and Ki-67 in Cutaneous Malignant Melanoma（CMM）,in order to explore Runx3＇ and Ki-67＇ effection during the generation and development of CMM.Methods Immunohistochemistry technique was perfomed to evaluate the alterations of the Runx3 and Ki-67 protein in CMM,Junction Nevus and normal skin tissues.Results The expression rate of Runx3 protein in the CMM,Junction Nevus and normal skin is 23.68%,85.00%,90.00%.There was a statical significance between the CMM and Junction Nevus or normal skin （P〈0.05）;The expression rate of Ki-67 protein in the CMM,Junction Nevus and normal skin is 78.95%,25.00%,25.00%.There was a statical significance between the CMM and Junction Nevus or normal skin （P〈0.05）.Conclusion The occurrence and development of CMM may be related to the low-expression rate of Runx3 protein and the high-expression rate of Ki-67 protein.