Current indications of lymphadenectomy in endometrial cancer |
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| Authors: | Bats A-S Bensaïd C Huchon C Scarabin C Nos C Lécuru F |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Nagoya Daini Red Cross Hospital, Nagoya, Japan;2. Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan;3. Department of Pathology, Nagoya Daini Red Cross Hospital, Nagoya, Japan;1. KK Women''s and Children''s Hospital, Department of Gynaecological Oncology, 100 Bukit Timah Road, Singapore 229899, Singapore;2. Duke-National University of Singapore Medical School, 8 College Road, Singapore 169857, Singapore;3. KK Women''s and Children''s Hospital, Department of Maternal-Foetal Medicine, 100 Bukit Timah Road, Singapore 229899, Singapore;1. Department of Obstetrics and Gynecology, Division of Gynecology Oncology, The Ohio State University, College of Medicine, 320 W 10th Avenue, M210 Starling Loving, Columbus, OH 43210, United States;2. Department of Obstetrics and Gynecology, Division of Gynecologic Specialties, University of California, Davis, 4860 Y Street, Suite 2500, Sacramento, CA 95817, United States;1. Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Bei Li Shi Road, Xi Cheng District, Beijing, 100037, China;2. Department of Cardiology, The Fifth Hospital of Wuhan & Affiliated Guangci Hospital of Wuhan University, Wuhan 430050, China |
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| Abstract: | Endometrial cancer is a tumor associated with a good prognosis as it is often diagnosed at an early stage. Up to 20 % of patients with stage I disease have a nodal involvement. Knowledge of nodal status provides important prognostic information. As preoperative assessment yields a poor value, prognostic lymphadenectomy appears to be indicated. However, therapeutic benefit of pelvic and para-aortic lymphadenectomy remains controversial. Recent randomized trials did not find any impact on survival for patients with low risk of nodal involvement. Thus, lymphadenectomy should no more be systematically performed in this low risk group. Nevertheless, pelvic and para-aortic lymphadenectomy seems to have a benefit in the high risk group, as isolated involved para-aortic nodes have been described. |
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