冠心病患者白细胞变形能力和粘附功能及细胞粘附分子表达的变化

为探讨白细胞变形能力、粘附功能和细胞粘附分子与冠心病的关系，检测了188例冠心病患者和68例健康人外周血白细胞滤过指数、粘附率、白细胞CD18表达和血清可溶性细胞间粘附分子-1浓度变化。结果发现，冠心病病人白细胞滤过指数、粘附率、白细胞CD18表达及可溶性细胞间粘附分子-1浓度均明显增高，与对照组比较差异有极显著性意义（P＜0．001）。急性心肌梗塞病人各指标增高较不稳定心绞痛和陈旧性心肌梗塞更明显（P＜0．001）、冠心病病人白细胞滤过指数、粘附率与白细胞CD18表达和可溶性细胞间粘附分子-1浓渡呈正相关（r=0．679～0．764，P＜0．001），白细胞滤过指数与粘附率呈正相关（r=0.663，P＜0．001）。提示白细胞变形能力降低，粘附功能和CD18表达及可溶性细胞间粘附分子-1浓度增高，参与了冠心病的发生，且与病情变化有关。

The Changes of Leukocyte Deformability, Leukocyte Adhesion Function and Expression of Cell Adhesion Molecules in Patients with Coronary Heart Disease

Aim To explore the correlation between thechanges of leukocyte deformability (LD), leukocyteadhesion function (LAF), expression of cell adhesionmolecule (CAM) and coronary heart disease (CHD).Methods Leukocyte filteration index (LFI), leuko-cyte adhesion rate (LAR), leukocyte CD18 expressionand serum soluble intercellular adhesion molecu1e-1(sICAM-1 ) were measured in 118 patients and 68 con-trols.Results LFI, LAR, leukocyte CD18 expression andsICAM-1 concentration were significantly higher in pa-tients than those in controls (P<0. 001 ),the increaseof all indicators were more obvious in acute myocardialinfarction(AMI) patients than those in unstable angina(UA) and old myocardial infarction (OMI) patients (P<0. 001). In CHD patients, the LAR and LFI werepositively correlaed to leukocyte CD18 expression andsICAM-1 concentration(P<0.001 ), the LFI was posi-tively correlated to the LAR(P<0. 001 ).Conclusions The decrease of LD and the increase ofLAF, leukocyte CD18 expression andsICAM-1 concentration might participate in the oecu-rance of CHD, and were closely related to the CHD pa-tients conditions.