L-精氨酸对冠心病高脂血症患者血脂、脂过氧化物及血液流变学的影响

对３０例冠心病高脂血症患者口服Ｌ－精氨酸治疗１月，观察其血脂，脂过氧化物，血液流变学的变化，及其与血浆精氨酸的关系。结果发现治疗后患者血清总胆固醇，甘油三酯，低密度脂蛋白，脂蛋白明显降低，而高密度脂蛋白升高；脂过氧化物明显降低，而超氧化物歧化酶活性增高；全血粘度低切变，血沉，血沉方程Ｋ值，红细胞聚集指数，血浆比粘度明显降低；同时伴有血浆精氨酸浓度明显增高。

Effects of L-arginine on Serum Lipid,Lipoprotein, Apolipoprotein, Lipid Peroxide and Hemorheology in Patients with Coronary Heart Disease and Hyperlipemia

Aim To investigate the effects of L-arginine on serum lipid, lipoprotein, lipid peroxide, and hemorhe-ology in petients with coronary heart diseasc and hy-perlipidema.Methods 4 tables (0. 25 g/tab )were given orally trice daily for 30 days in 30 patients with coronary heart disease and hyperlipemia. The serum lipid,lipoprotein apolipoprotein, lipid peroxide and hemorheology were meassured be fore and after treat-ment.Results L-arginine could significantly reduce serum total cholesterol, triglyceride, low density lipoprotein cholesterol and lipoprotein(a) levels (p<0. 01), but increase high density lipoprotein choles-terol level (p< 0.05). L-arginine could greatly lower lipid Peroxide level (p<0. 01 ),but increase su-Perokide dismutase activity(p<0. 01 ). L-arg-inine could decrease low shear of blood speific viscosi-ty, erythrocyte sedimentation rate (ESR),equation K value of ESR,aggregative index of red blood cell and plasma specific viscosity (p<0.01 ). An increase of plasma arginine level was companied with the above changes.Conclusions L-arginine releasing nitric oxide in vi-vo can suppress hyperlipemia and lipid Peroxide and improve helnorhfology in patitnts with coronary heart disease. Thus L-arginine may be used to treat coro-nary heart disease an byperliPemia.