实验性高血压所致的颅内大动脉损害

为观察实验性高血压所致的颅内大动脉损害的特征．将易卒中型肾血管性高血压大鼠的大脑中动脉和基底动脉进行形态学测量．并观察了用卡托普利抗高血压治疗后这些测量参数的变化。结果发现，高血压大鼠的大脑中动脉和基底动脉均有中层肥厚，但前者主要由平滑肌细胞增殖、肥大引起，后者却主要是血管壁重构的结果。卡托普利抗高血压治疗可控制平滑肌细胞增殖、肥大，但不能改善血管壁重构。以上结果提示，高血压所致的颅内动脉损害主要表现为血管中层肥厚，而且不同血管对高血压和抗高血压治疗的反应有差异。

Intracranial Large Arterial Lesions Induced by Experimental Hypertension

Aim To observe the characteristic of intracranial large arterial lesions that were induced by experimental hypertension.Methods A morphometric study was performed on middle cerebral artery and basal artery in stroke-prone renovascular hypertensive rats and the morphometric values afert antihypertensive therapy with captopril were compared with those in non-antihypertensive rats.Results It was found that enhanced media thickness was presented in both middle cerebral artery and basal artery. It was mainly induced by hypertrophy and hyperplasia of smooth muscle cells in middle cerebral artery and by mural remodeling in basal artery. The hypertrophy and hyperplasia of smooth muscle cells were depressed, but the remodeling did not reverse to be sufficient to bring about full normalization after antihypertensive therapy.Conclusion These results indicate that the main lesion of intracranial arteries is enhanced media thickness, but different vessels have different reaction to hypertension and antihypertensive therapy.