Use of Voriconazole to Successfully Treat Disseminated <Emphasis Type="Italic">Trichosporon asahii</Emphasis> Infection in a Patient with Acute Myeloid Leukaemia |
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| Authors: | S Fournier W Pavageau M Feuillhade S Deplus A-M Zagdanski O Verola H Dombret J Molina |
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| Institution: | (1) Department of Infectious Diseases, Saint Louis Hospital, 1 Avenue Claude Vellefaux, 75010 Paris, France,;(2) Laboratory of Parasitology, Saint Louis Hospital, Paris, France,;(3) Division of Ophthalmology, Saint Louis Hospital, Paris, France,;(4) Division of Radiology, Saint Louis Hospital, Paris, France,;(5) Division of Anatomopathology, Saint Louis Hospital, Paris, France,;(6) Division of Hematology, Saint Louis Hospital, Paris, France, |
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| Abstract: | Trichosporon spp. is an emerging fungal pathogen in immunocompromised hosts, and disseminated infection is often fatal in neutropenic
patients. Reported here is a case of disseminated infection in a neutropenic patient with acute leukaemia. After failure of
amphotericin B and fluconazole therapy, the course of infection dramatically improved with voriconazole treatment. A literature
search revealed 69 additional cases of disseminated Trichosporon spp. infections in neutropenic patients, and these are also reviewed. Clinical symptoms that suggest infection include fever,
disseminated papulopustular cutaneous lesions and pulmonary involvement. Despite treatment with antifungal agents (amphotericin
B, fluconazole), 78% of patients died. Voriconazole may represent a promising therapy for this life-threatening infection.
Electronic Publication |
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