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c-FLIP does not correlate with response to immunochemotherapy treatment and outcome of patients with nodal diffuse large B-cell lymphoma |
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| Authors: | Olivera Markovic Dragomir Marisavljevic Vesna Cemerikic-Martinovic Branka Filipovic Slavica Radovanović Marija Zdravković Dejana Stanisavljevic Biljana Mihaljevic |
| Affiliation: | 1. Clinical Hospital Center “Bezanijska kosa”, Belgrade, Serbia;2. Beolab, Belgrade, Serbia;3. Institute of Hematology, Clinical Center of Serbia, Belgrade, Serbia;4. Institute of Statistic, Clinical Center of Serbia, Belgrade, Serbia;5. Faculty of Medicine, University of Belgrade, Belgrade, Serbia |
| Abstract: | Cellular FLICE-inhibitory protein (c-FLIP) is a critical anti-apoptotic regulator that inhibits apoptosis-inducing ligand, (TRAIL)-induced apoptosis as well as chemotherapy-triggered apoptosis in malignant cells. The present study was designed to investigate the clinical and prognostic significance of c-FLIP expression in patients with nodal diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy. |
| Keywords: | Diffuse large B-cell lymphoma c-FLIP Apoptosis Immunohistochemistry Prognosis |
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