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正交法优选扑感敏片制备工艺
引用本文:朱建明,曾国栋. 正交法优选扑感敏片制备工艺[J]. 中国药师, 2003, 6(6): 348-348,350
作者姓名:朱建明  曾国栋
作者单位:厦门建发制药有限公司,福建,厦门,361001
摘    要:目的:优选扑感敏片制备工艺,提高产品质量。方法:采用正交实验方法对工艺进行优化。结果:优化后的工艺,产品的脆碎度由原工艺的0.8%--1.0%降低到0.2%--0.4%;崩解度由原工艺的10--12min下降到4—7min;片重差异均在合格范围。结论:优化后的工艺使扑感敏片的质量指标明显提高,生产效率也明显得到提高,工艺切实可行。

关 键 词:正交法 扑感敏片 制备工艺
文章编号:1008-049X(2003)05-0348-02

Optimization of Preparative Technology of PGM Tablet by Orthogonal Method
Zhu Jianming,Zeng Guodong. Optimization of Preparative Technology of PGM Tablet by Orthogonal Method[J]. China Pharmacist, 2003, 6(6): 348-348,350
Authors:Zhu Jianming  Zeng Guodong
Abstract:Objective: To obtain a higher quality of PGM tablet by optimization of preparative technology.Methods: The optimization of technology was conducted according to the orthogonal method.Results: The tablet friability was raised from 0.8% 1.0% to 0.2% 0.4% ,The disintegration was reduced from 10 12 min to 4 7 min, The weight variation coincided with specify after optimization of technology.Conclusion: The quality and efficiency of the Optimized technology are more available than the original technology.
Keywords:Orthogonal method  PGM tablet  Preparative technology  
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