| 紫色疣石磺化学成分的分离与鉴定 |
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| 引用本文： | 孙变娜,沈和定,吴洪喜,姚理想,程知庆. 紫色疣石磺化学成分的分离与鉴定[J]. 中国药房, 2014, 0(11): 1019-1021 |
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| 作者姓名： | 孙变娜 沈和定 吴洪喜 姚理想 程知庆 |
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| 作者单位： | [1]上海海洋大学省部共建水产种质资源发掘与利用教育部重点实验室,上海201306 [2]浙江省海洋水产养殖研究所,浙江温州325005 [3]浙江省近岸水域生物资源开发与保护重点实验室,浙江温州325005 |
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| 基金项目： | 国家自然科学基金资助项目（No.41276157） |
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| 摘 要： | 目的:对海洋贝类紫色疣石磺的化学成分进行分离与鉴定。方法:使用常压硅胶柱色谱法对紫色疣石磺甲醇提取物的石油醚和乙酸乙酯部位进行化学成分研究,通过理化性质和波谱数据对分离得到的化合物进行结构鉴定。结果:从紫色疣石磺中分离得到5个化合物,分别鉴定为2,2′-氧代双(1,4-二叔丁苯)(1)、胆甾醇(2)、α-棕榈精(3)、尿嘧啶(4)、胸腺嘧啶(5)。其中,化合物1为首次以天然产物形式分离得到,所有化合物均为首次从该属种中分离得到。结论:该试验可为石磺科动物药材的进一步研究提供科学依据。
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| 关 键 词： | 紫色疣石磺 化学成分 提取分离 结构鉴定 海洋中药 |
Isolation and Identification of Chemical Constituents from Peronia verruculata |
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| SUN Bian-na,SHEN He-ding,WU Hong-xi,YAO Li-xiang,CHENG Zhi-qing. Isolation and Identification of Chemical Constituents from Peronia verruculata[J]. China Pharmacy, 2014, 0(11): 1019-1021 |
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| Authors: | SUN Bian-na SHEN He-ding WU Hong-xi YAO Li-xiang CHENG Zhi-qing |
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| Affiliation: | 1.Key Laboratory of Explora- tion and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China; 2. Zhejiang Mariculture Research Institute, Zhejiang Wenzhou 325005, China; 3. Zhejiang Key Lab of Exploitation and Preservation of Coastal Bio-Resource, Zhejiang Wenzhou 325005, China) |
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| Abstract: | OBJECTIVE： To isolate and identify chemical components of Peronia verruculata. METHODS： Silica gel column chromatography was used to isolate components from petroleum ether and ethyl acetate fractions of methanol extract from P. ver- ruculata. Their structures of isolated components were elucidated by spectrum data and physical and chemical properties. RE- SULTS ： 5 compounds were obtained and elucidated as 2,2＇ -oxybis （1,4-di-tert-butylbenzene） （1）, cholesterol （2）,α-monpalmitin （3）, uracil （4）, thymine （5）. Among them, compound 1 was reported as a natural product for the first time, and all of these com- pounds were isolated from P. verruculata for the first time. CONCLUSIONS： These data provides a reference for further study of Onchidium hongkongensis as animal medicines. |
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| Keywords: | Peronia verruculata Chemical constituents Extraction and isolation Structural identification Marine TCM |
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