| Abstract: | Hypophysectomy in rats is followed by a significant increase in polynucleotide-phosphorylase (PNPase) activity in ribosomal fractions of the liver. Injection of growth hormone into hypophysectomized animals leads to inhibition of PNPase activity. Within the dose range from 5 to 100  g the dose—effect curve is linear. The action of growth hormone is most marked 18h after a single injection.Laboratory of Enzymology, Academy of Medical Sciences of the USSR, and Laboratory of Biological Standardization of Hormones, Institute of Experimental Endocrinology and Hormone Chemistry, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 2, pp. 162–163, February, 1980. |
