应用胸部CT和血清CYFRA21-1、NSE检测诊断肺癌

目的:探讨胸部CT和血清CYFRA21-1、NSE检测及其联合应用诊断肺癌的价值.方法:选择肺肿瘤患者60例,全部行胸部CT检查和血清CYFRA21-1、NSE 二种肿瘤标志物检测,分别计算二种方法诊断肺癌的灵敏度、特异性和准确性并加以比较.结果:CT诊断肺癌灵敏度为91.3%,特异性为71.4%,准确性为86.7%;CYFRA21-1、NSE诊断肺癌灵敏度为71.7%,特异性为85.7%,准确性为75.0%;CT诊断肺癌具有较高的灵敏度,但特异性较低,而血清CYFRA21-1、NSE诊断肺癌灵敏度较低,但特异性较高.结论:胸部CT和血清CYFRA21-1、NSE检测在肺癌的诊断中具有重要价值,二者联合应用诊断肺癌具有互补作用.

Diagnosis of Pulmonary Carcinoma by Chest CT and Detection of Serum CYFRA21-1, NSE Levels

Objective To investigate the value of chest CT and detection of serum CYFRA21 - 1 ,NSE in diagnosis of pulmonary carcinoma. Methods Chest CT were performed and serum levels of CYFRA21 - 1 and NSE were measured with RIA in 60 patients with pulmonary nodules, the sensitivity, specificity and accuracy of two methods fir diagnosis of cancer were compared. Results The sensitivity,speeifieity and accuracy of the chest CT were 91.3% ,71.4% and 86.7% respectively, and with detection of serum CYFRA21 - 1 and NSE were 71.7% ,85.7% and 75.0%. Chest CT had higher sensitivity but lower specificity,and the reverse was true with detection of serum CYFRA21 - 1 and NSE. Conclusion Both of chest CT and detection of serum CYFRA21 - 1 and NSE are important methods in diagnosis of pulmonary carcinoma and they are complementary to each other .