内膜下血管成形术治疗下肢动脉慢性缺血

目的 探讨内膜下血管成形术治疗下肢动脉慢性缺血的技术可行性、通畅率和临床效果.方法 回顾性分析2003年12月至2008年8月应用内膜下血管成形术(subintimal angioplasty,SIA)治疗的112例患者的122条动脉硬化闭塞患肢的临床资料,动脉闭塞平均长度为10.25 cm(4.5～28 cm),其中23条肢体为生活方式受限性间歇性跛行,99条为严重性缺血.详细纪录患者的病史、病变特点、操作技术过程、并发症和随访信息.采用Kaplan-Meier生存分析法分析患肢通畅率和临床效果(救肢和症状改善).结果 SIA技术成功率为83%,成功进行SIA的患者平均踝肱指数从0.19±0.11增加到0.67±0.29(P<0.01),1年、2年冉管化通道的通畅率和临床有效率分别是54%±5%、45%±4%和82%±5%、79%±4%.没有严重后果的并发症发生. 结论 SIA技术成功率高,临床效果满意,本组无严重并发症,是一种治疗下肢动脉粥样硬化闭塞所致慢性缺血较好可供选择的治疗手段.

Subintimal angioplasty for the treatment of chronic ischemia with arteriosclerosis occlusions in the lower extremity

Objective To assess the technical feasibility, patency and outcomes of subintimal angioplasty (SIA) for treatment of the lower extremity arteriosclerosis occlusions. Methods During the period from December 2003 to August 2008, 122 lower extremities with arteriosclerosis occlusions (median length, 10.25 cm;range, 4.5 to 28 cm) were treated on an intention-to-cure basis with SIA. Twenty-three lower extremities had disabling claudication and ninety-nine had limb-threatening ischemia. Patient history, demographics, procedural details, complications, and follow-up information were collected and analyzed. Patency, limb salvage, sustained improvement in claudication was determined by Kaplan-Meier analysis. Results The technical success rate of SIA was 83%. Following successful SIA, the mean ankle-brachial index increased from 0.19±0.11 to 0.67±0.29 (P<0.01). Primary patency at 12 and 24 months was 54%±5% and 45%±4% respectively, the clinical effective rates (rates of limb salvage and improvement in claudication) at 12 and 24 months were 82%±5% and 79%±4% respectively. No serious complications occurred. Conclusion In a selected group of patients, SIA is feasible with a high technical success rate and the clinical effective rates are satisfactory, there were no severe complications. SIA is a good treatment alternative in patients suffering from chronic ischemia with arteriosclerosis occlusions in the lower extremity.