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Effect of type I collagen on the adhesion, proliferation, and osteoblastic gene expression of bone marrow-derived mesenchymal stem cells
作者姓名:刘刚  胡蕴玉  赵建宁  吴苏稼  熊卓  吕荣
作者单位:Department of Orthopedics,Nanjing General Hospital,Nanjing Military District,Nanjing,Jiangsu 210001,China,Institute of Orthopedics of Xijing Hospital,Fourth Military Medicical University,Xi'an,Shanxi,China,Department of Orthopedics,Nanjing General Hospital,Nanjing Military District,Nanjing,Jiangsu 210001,China,Department of Orthopedics,Nanjing General Hospital,Nanjing Military District,Nanjing,Jiangsu 210001,China,Department of Mechanical Engineering of Tsinghua University,Beijing,China,Institute of Orthopedics of Xijing Hospital,Fourth Military Medicical University,Xi'an,Shanxi,China
基金项目:TheNinthFive YearPlanProjectonNewMaterialintheStateHi TechPlan (0 0 9 0 16 0 ),KeySubjectfundedbytheArmyMedicamentandHealthScientificSearchFund,No .0 1Z0 79
摘    要:tificially synthesizedpolymericproductssuchaspolylactide (PLA ) ,polyglycolide (PGA ) ,andtheircopolymersarefrequently usedtissueengineeringmatrixsubstitutivematerials .Unfortunately ,theirapplicationisseriouslyrestrictedfortheirpoorhydrophilicproperty ,weakcelladsorptionforces ,anddifficultyininteractionwithcells .1,2 ThisstudyintendstoevaluatethecapacityofcollagenIinpromotingadhesion ,proliferation ,anddifferentiationofMSCs ,tolayanexperimentalbasisforbonytissueengineering .METHODSPrep…

关 键 词:间叶细胞  干细胞  骨髓  细胞粘附力  PLGA  OPN  RNA  ALP  MSC  RT-PCR

Effect of type I collagen on the adhesion, proliferation, and osteoblastic gene expression of bone marrow-derived mesenchymal stem cells
Gang Liu,Yun-Yu Hu,Jian-Ning Zhao,Su-Jia Wu,Zhuo Xiong,Rong Lu.Effect of type I collagen on the adhesion, proliferation, and osteoblastic gene expression of bone marrow-derived mesenchymal stem cells[J].Chinese Journal of Traumatology(English Edition),2004,7(6):358-362.
Authors:Gang Liu  Yun-Yu Hu  Jian-Ning Zhao  Su-Jia Wu  Zhuo Xiong  Rong Lu
Institution:1. Department of Orthopedics, Nanjing General Hospital, Nanjing Military District, Nanjing, Jiangsu,210001, China
2. Institute of Orthopedics of Xijing Hospital, Fourth Military Medicical University, Xi'an, Shanxi, China
3. Department of Mechanical Engineering of Tsinghua University, Beijing, China
Abstract:
Keywords:Mesenchymal stem cells  Collagen  type-Ⅰ  Cell adhesion
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