抑癌基因PTEN在泌尿系肿瘤发生发展中的作用

第10号染色体同源丢失性磷酸酶-张力蛋白基因(PTEN)具有磷酸酶活性及抑癌活性。PTEN的突变缺失是包括泌尿系肿瘤等各种肿瘤发生发展的基础。研究显示,由于PTEN的突变、缺失而丧失抑癌作用而致肾癌、膀胱癌、前列腺癌的发生,揭示了PTEN具有抑制泌尿系肿瘤发生的作用。但是,PTEN抑癌作用及丢失、突变的一些具体过程还不是很清楚,有待进一步的明确。

The Study of Tumor Suppressor Gene PTEN in the Carcinoma of Urinary System

PTEN（ phosphatase and tensin homolog deleted on chromosome ten）is phosphatase specificity and can inhibit oncogenesis. The mutation and loss of PTEN is the oncogenesis basis of all kinds of tumor, including urinary system tumor. Studies show that mutation and loss of PTEN, which can lead to the dysfunction of tumor suppress, induced oncogcnesis of renal cell carcinoma, bladder carcinoma and prostatic carcinoma, revealling that PTEN can inhibit tumorigenesis of urnary system. But the detail of the mutation and loss of PTEN and how PTEN inhibit tumorigensis are still unclear,further study is warranted.