Sensitivity of cultured embryonic heart cells to cardiotoxin obtained from Naja naja siamensis venom. |
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Authors: | K Arms D McPheeters |
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Institution: | Section of Neurobiology and Behavior, Langmuir Laboratory, Cornell University, Ithaca, New York 14853, U.S.A. |
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Abstract: | Clumps of embryonic chick heart cells in culture were exposed to cardiotoxin prepared by Sephadex CM-50 fractionation from snake (Naja naja siamensis) venom. Cardiotoxin irreversibly depolarized these cells. More of the cells cultured from 4-day embryos, than from 12–13-day embryos, continued to beat spontaneously after 30 min exposure to the toxin at a concentration of 15–20 μg per ml. |
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