Kinetics of antibody response to hepatitis B virus determinants and to recombinant vaccines in Italy. |
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| Authors: | A R Zanetti E Tanzi L Romano P Vigano A Cargnel S Hojvat A J Zuckerman |
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| Affiliation: | Institute of Virology, University of Milan, Italy. |
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| Abstract: | The kinetics of antibody response to the group determinant a and subdeterminants d and y of hepatitis B virus were studied after infection and following immunisation with two recombinant DNA yeast-derived hepatitis B vaccines. The initial antibody response was to the subdeterminant epitopes, whereas anti-a antibody, which provides protection against different subtypes of the virus, was not detected for some weeks or months. The delay in the development of anti-a antibody after active immunisation raises important issues of early protection against infection. |
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| Keywords: | hepatitis B group determinant a subtype determinants recombinant vaccines |
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