Listeria monocytogenes reactive T lymphocytes in healthy individuals |
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Authors: | M E Munk S H Kaufmann |
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Affiliation: | Max-Planck-Institut für Immunobiologie, Freiburg, FRG. |
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Abstract: | Peripheral blood mononuclear cells of healthy individuals were enriched for T lymphocytes and stimulated with killed organisms of Listeria sp. Different strains of Listeria sp. induced comparable T cell responses independent from their pathogenicity and virulence. Evidence is presented that killed L. monocytogenes organisms lacked mitogenic activity for human B and T lymphocytes. It is concluded that Listeria reactive T lymphocytes are commonly present in healthy individuals and hence may contribute to the rare occurrence of listeriosis in normal adults. |
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