| 重组核衣壳蛋白用于肾综合征出血热病人IgG抗体检测 |
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| 引用本文： | 刘京梅,李泉根,刘元东,周先志,徐德忠.重组核衣壳蛋白用于肾综合征出血热病人IgG抗体检测[J].疾病监测,2002,17(12):445-449. |
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| 作者姓名： | 刘京梅 李泉根 刘元东 周先志 徐德忠 |
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| 作者单位： | 1.第四军医大学军队流行病教研室 710032; |
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| 摘 要： | 目的检测肾综合征出血热病人的IgG抗体及发现在我国可能存在的新的血清型。方法 用五种血清型汉坦病毒核衣壳重组蛋白作抗原建立间接ELISA法,检测HFRS病人血清中特异性IgG。结果检测了91份病人血清,发现我国山东、北京地区的汉坦病毒感染以HTN血清型群为主(56.1％);首次检测到2份疑似DOB型病毒感染血清。结论我国有可能存在DOB病毒血清型。
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| 关 键 词： | 汉坦病毒 重组核衣壳蛋白 ELISA |
| 文章编号： | 1003-9961(2002)12-0445-04 |
| 收稿时间： | 2002-10-03 |
| 修稿时间： | 2002年10月3日 |
Detection of Serological serotypes of Hantavirus Infections by Recombinant Nucleocapsid Proteins and Discovery of DOB Serotype in China |
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| LIU Jing - Mei,et al.Detection of Serological serotypes of Hantavirus Infections by Recombinant Nucleocapsid Proteins and Discovery of DOB Serotype in China[J].Disease Surveillance,2002,17(12):445-449. |
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| Authors: | LIU Jing - Mei |
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| Institution: | 1.Department of Epidemiology the Fourth Military Medical University |
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| Abstract: | Objective To detect the IgG of HFRS patient sera and find new serotypein in China. Methods The indirect ELISA was established based on 5 different recombinant NP antigens. The specific IgG of HFRS patient sera were determined.Results Out of 91 sera,57 was positive of specific antibody (62.6%);The majority of the sera (32/ 57)were belong to HTNgroup. ( sera were multiple - type (React to 5 different antigens,but no significant difference was found between individual A450). And 2 sera were determined as DOB serotype. Conclusions The results of the sero-logical evidence indicate that DOB serotype might exist in China. |
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| Keywords: | Hantanvirous recombinant nucleocapsid protein serotype DOB ELISA |
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