艾滋病患者慢性胃炎胃黏膜上皮细胞超微结构特点

目的探讨艾滋病患者慢性胃炎胃黏膜上皮细胞损伤特点。方法随机抽取在本院住院有消化道症状的10例艾滋病患者进行胃镜检查,同时随机抽取在本院住院的有消化道症状的普通人群进行胃镜检查。所有患者都在相同部位取活体组织进行电镜检查。结果艾滋病患者胃黏膜细胞的线粒体肿胀、空泡变性和密度增高,细胞质里有解聚的核糖体,粗面内质网、高尔基体有不同程度的扩张。胃黏膜细胞可见不同期凋亡。普通人群胃黏膜在透射电镜观察仅显示胃黏膜细胞的线粒体呈现不同程度的肿胀。可见有上皮细胞坏死。结论艾滋病患者慢性胃炎胃黏膜上皮细胞损伤程度比普通人群重。其机制目前还不十分清楚。

Ultrastructural characteristics of gastric mucosal epithelial cells of AIDS patients complicated with chronic gastritis

Objective To investigate ultrastructural features of gastric mucosal epithelial cells of AIDS patients complicated with chronic gastritis. Methods Ten AIDS patients with alimentary tract symptoms underwent gastroscopy and biopsy of gastric mucosa was performed by random method. All the biopsy specimens were examined by electron microscopy. Results There were swelling, vacuolar degeneration and increased density of mitochondria, dissociated ribosomes in the cytoplasm,and dilation of rough endoplasmic reticulum and Golgi's apparatus. Some gastric mucosal cells were in different stages of apoptosis. The gastric mucosal cells of the control subjects with chronic gastritis but without AIDS showed swelling of mitochondria to different extents and necrosis of epithelial cells.Conclusion Injuries of gastric mucosal epithelial cells of AIDS patients complicated with chronic gastritis may be more severe than those seen in the control subjects and the mechanism of the more severe injuries is unclear.