纤维蛋白酶原与胆碱酯酶在乙型肝炎肝硬化肝储备功能评估中的应用研究

目的探讨纤维蛋白酶原与胆碱酯酶在乙型肝炎肝硬化肝储备功能评估中的应用。方法选取2007年1月—2009年12月河南宏力医院就诊的乙型肝炎肝硬化患者165例,按照Child-Pugh分级标准分为3组：A组65例,B组58例,C组42例。在同时期健康体检人群中匹配56例为对照组。分别检测各组血浆纤维蛋白酶原及血清胆碱酯酶水平。结果对照组、A组、B组、C组血浆纤维蛋白酶原水平分别为（3.09±0.51）g/L、（2.98±0.55）g/L、（2.58±0.64）g/L、（1.94±0.57）g/L;胆碱酯酶分别为（8137±238）U/L、（6854±453）U/L、（4426±674）U/L、（2317±148）U/L。C组、B组纤维蛋白酶原、胆碱酯酶水平与A组比较,C组与B组比较差异有统计学意义（P〈0.05）;A组与对照组胆碱酯酶水平比较差异有统计学意义（P〈0.05）,而两组纤维蛋白酶原水平比较差异无统计学意义（P〉0.05）。结论血清纤维蛋白酶原、胆碱酯酶可作为乙型肝炎肝硬化患者肝储备功能评估的重要指标。

Value of Fibrinogen and Cholinesterase Activity in Evaluating Liver Reserve Function of Hepatitis B Cirrhosis Patients

Objective To investigate the Value of Fibrinogen and Cholinesterase Activity in Evaluating Liver Reserve Function of Hepatitis B Cirrhosis Patients.Methods 165 cases of patients suffered from hepatitis B cirrhosis treated in Henan Honliv Hospital from January 2007 to December 2009 are divided into 3 groups named A,B,C respectively,according to Child-Pugh score.56 healthy individuals are choised as a control group.Fibrinogen and Cholinesterase Activitv were measured.Results The levels of Fibrinogen in difference group are as follows： Group Control（3.09 ± 0.51） g /L,Group A（2.98 ± 0.55） g / L,Group B（2.58 ± 0.64） g / L,Group C（1.94 ± 0.57） g / L.The levels of Cholinesterase Activity in difference group are as follows： Group Control（8137 ± 238） U / L,Group A（6854 ± 453） U / L,Group B 组（4426 ± 674） U / L,Group C（2317 ± 148） U / L.The levels of Fibrinogen and Cholinesterase Activity in Group C and Group B are less than Group B and Group A respectively;The levels of Fibrinogen in Group A are equal to Group Control,However The levels of Cholinesterase Activity in Group A are less as compared to Group Control.Some patiences with hepatitis B cirrhosis whose levels of Fibrinogen and Cholinesterase Activity rise when they were treated with combined modality therapy,on the contrary whose classification of Child-Pugh decrease.Conclusion Fibrinogen and Cholinesterase Activity are important indexes to evaluate liver reserve function of Hepatitis B Cirrhosis Patients.