| 乌鸡白凤丸对去卵巢大鼠脂代谢的影响 |
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| 引用本文： | 王鑫国,葛喜珍,马嵬,徐华洲,窦玉红. 乌鸡白凤丸对去卵巢大鼠脂代谢的影响[J]. 中成药, 2003, 25(5): 396-398 |
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| 作者姓名： | 王鑫国 葛喜珍 马嵬 徐华洲 窦玉红 |
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| 作者单位： | 1. 河北医科大学中医学院,石家庄,050091
2. 深圳金话-洲制药有限公司,广东深圳 |
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| 摘 要： | 目的：探讨乌鸡白凤丸抗动脉硬化机制。方法：采用去大鼠卵巢的方法建立脂代谢紊乱模型，观察血脂、脂蛋白、脂质过氧化物的变化。结果：乌鸡白凤丸治疗12周后，甘油三脂(TG)、氧化低密度脂蛋白(OX—LDL)和丙二醛(MDA)明显较去卵巢组降低(P＜0．05或P＜0．01)，高密度脂蛋白(HDL—c)、载脂蛋白A(apo-A I)和超氧化物歧化酶(SOD)活力明显较去卵巢组升高(P＜0．05或P＜0．01)。结论：乌鸡白凤丸抗动脉硬化机制与其调节血脂、抗氧化有关。
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| 关 键 词： | 乌鸡白凤丸 去卵巢大鼠 血脂 脂蛋白 脂代谢 抗动脉硬化作用 |
| 文章编号： | 1001-1528(2003)05-0396-03 |
| 修稿时间： | 2002-07-05 |
Effects of Wujibaifeng Pills on lipid metabolic changes in ovariectomized rat |
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| WANG Xin-guo,GE Xi-zhen,MA Wei,XU Hua-zhou,CAO Gang. Effects of Wujibaifeng Pills on lipid metabolic changes in ovariectomized rat[J]. Chinese Traditional Patent Medicine, 2003, 25(5): 396-398 |
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| Authors: | WANG Xin-guo GE Xi-zhen MA Wei XU Hua-zhou CAO Gang |
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| Affiliation: | WANG Xin-guo1,GE Xi-zhen1,MA Wei2,XU Hua-zhou1,CAO Gang1 |
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| Abstract: | Objective: To investigate the antiatherosclerotic effect of Wujibaifeng Pills and its mechanism. Methods: Rat dyslipidema was induced by ovariectomy (OVX), the levels of serum lipids, superoxide dismutase (SOD) activities and malondialdehyde (MDA) were detected after 12 weeks with the treatment of wujibafeng pills. Results: Wujibaifeng Pills lowered serum oxidized-low density lipoprotein cholesterol (OX-LDL,P< 0.01 ), triglyceride (TG,P<0.01), MDA(P<0.05 or P<0.01) and enhanced serum high desity lipoprotion cholesterol (HDL-C, P<0.05 or P<0.01), apolipoprotein A I (apo-AI, P<0.01) and SOD activities (P<0.01). Conclusion: Wujibaifeng Pills can adjust serum lipids, increase lipid SOD activities and decrease MDA contents in ovariectomized rats, with relation to inhibiting atherosclerosis. |
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| Keywords: | Wujibaifeng Pills ovariectomized rats blood fat apolipoprotein |
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