Mitochondrial DNA rearrangements associated with mF plasmid integration and plasmodial longevity in Physarum polycephalum |
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| Authors: | Catherine Curtis Nakagawa Elsy Perez Jones D L Miller |
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| Institution: | (1) Department of Molecular and Cell Biology, The University of Texas at Dallas, Richardson, TX 75080, USA Fax: 972-883-2409 e-mail: dmiller@utdallas.edu, US;(2) Department of Microbiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA, US |
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| Abstract: | Plasmodial cultures of Physarum polycephalum have defined life spans and undergo a reproducible decline (senescence) before losing the ability to be subcultured. Studies
of the mtDNA of a long-lived Physarum strain, which does not undergo senescence, revealed a 7.9-kb insertion in its mtDNA. This insertion is derived from a mitochondrial
plasmid which enhances mitochondrial fusion and mtDNA recombination. Four different recombination events are required to convert
the parental mtDNA to the form found in the long-lived strain. An additional recombination event, which deletes a 2.4-kb region
of the insert from the long-lived strain, has been identified in the mtDNA of a normally senescing strain. These observations
imply a mitochondrial involvement in the process of plasmodial senescence and implicate a region of the DNA derived from the
mitochondrial plasmid as being necessary for plasmodial longevity.
Received: 11 August / 18 November 1997 |
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| Keywords: | Physarum polycephalum Plasmodial senescence Mitochondrial DNA Mitochondrial plasmid |
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