| 自拟化瘀润肠方对顽固性便秘模型小鼠结肠间质细胞的影响 |
| |
| 引用本文： | 李国峰.自拟化瘀润肠方对顽固性便秘模型小鼠结肠间质细胞的影响[J].世界中西医结合杂志,2011,6(9):806-808. |
| |
| 作者姓名： | 李国峰 |
| |
| 作者单位： | 长春中医药大学附属医院,吉林,长春,130021 |
| |
| 基金项目： | 吉林省科技厅青年基金项目 |
| |
| 摘 要： | 目的探讨化瘀润肠方治疗便秘的机理。方法采用吗啡皮下注射方法复制顽固性便秘小鼠模型,观察便秘模型小鼠是否存在结肠间质细胞（ICC）的变化,通过药物治疗后是否会恢复ICC的功能和结构。结果便秘模型小鼠与空白组小鼠比较I,CC数量明显减少（P〈0.05）,各药物组与模型组比较,小鼠结肠ICC数量均有提高（P〈0.05）,但化瘀润肠方大剂量组作用程度明显优于中剂量组（P〈0.05）,中剂量组明显优于麻仁软胶囊组（P〈0.05）,麻仁软胶囊组优于莫沙比利组（P〈0.05）,莫沙比利组与化瘀润肠方小剂量组比较,差异无统计学意义（P〉0.05）。免疫荧光与激光共聚焦显微镜扫描观察小鼠结肠ICC变化,发现化瘀润肠方中、大剂量组能够恢复便秘小鼠ICC结构。结论便秘模型小鼠结肠ICC存在形态及数量异常,化瘀润肠方能够增加便秘模型小鼠结肠ICC的数量。
|
| 关 键 词： | 便秘 结肠间质细胞 中医药 |
Influence on ICC Treated with Self-Prepared Formula for Removing Stasis and Moistening the Intestine for the Mouse Model with Intractable Constipation |
| |
| LI Guo-feng.Influence on ICC Treated with Self-Prepared Formula for Removing Stasis and Moistening the Intestine for the Mouse Model with Intractable Constipation[J].World Journal Of Integrated Traditional and Wesrern Medicine,2011,6(9):806-808. |
| |
| Authors: | LI Guo-feng |
| |
| Institution: | LI Guo-feng(Affiliated Hospital of Changchun University of Traditional Chinese Medicine,Changchun Jilin 130021) |
| |
| Abstract: | Objective To explore the mechanism on constipation treated with the formula for removing stasis and moistening the intestine.Methods The subcutaneous injection of morphine was adopted to duplicate the mouse models of intractable constipation.It was to observe whether the changes of interstitial cells of Cajal(ICC)were induced and whether the function and structure of ICC were recovered after treatment.Results In comparison with the mice in blank group,ICC count for the constipation models decreased obviousl... |
| |
| Keywords: | Constipation ICC Traditional Chinese medicine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
