| 五味子影响黄药子肝肾毒性的实验观察 |
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| 引用本文： | 杨辉,李多娇,王彦云,牟稷征,崔向青,李冀湘,杨承,李连颖,杨洋,苑景春.五味子影响黄药子肝肾毒性的实验观察[J].临床药物治疗杂志,2008,6(1):29-34. |
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| 作者姓名： | 杨辉 李多娇 王彦云 牟稷征 崔向青 李冀湘 杨承 李连颖 杨洋 苑景春 |
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| 作者单位： | 1. 中国中医科学院广安门医院,北京,100053
2. 北京中医药大学基础医学院,北京,100029 |
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| 基金项目： | 中国中医科学院广安门医院所级科研课题 |
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| 摘 要： | 目的观察五味子与黄药子合用时,对黄药子所致生化及肝肾病理改变的缓解作用。方法对比黄药子组、拮抗组小鼠在给药60d后观察肝脏生化指标、病理。结果拮抗各剂量组对相应剂量黄药子所致的ALT升高及病理改变有明显的缓解和抑制作用。
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| 关 键 词： | 黄药子 五味子 拮抗 肝肾损害 |
| 文章编号： | 1672-3384（2008）-01-0029-06 |
Study on the effect of the Schisandra chinensis(Turcz.) Baill on the hepanic and renal toxicity of Dioscorea bulbifera L. |
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| Yang Hui,Li Duo-jiao,Wang Yan-yun,Mou Ji-zheng,Cui Xiang-qing,Li Ji-xang,Yang cheng,Li liang-ying,Yang Yang,yuan Jing-chun.Study on the effect of the Schisandra chinensis(Turcz.) Baill on the hepanic and renal toxicity of Dioscorea bulbifera L.[J].Clinical Medication JOurnal,2008,6(1):29-34. |
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| Authors: | Yang Hui Li Duo-jiao Wang Yan-yun Mou Ji-zheng Cui Xiang-qing Li Ji-xang Yang cheng Li liang-ying Yang Yang yuan Jing-chun |
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| Institution: | Yang Hui, Li Duo-jiao, WanglYan-yun,Mou Ji-zheng, Cui Xiang-qing,Li Ji-xang, Yang cheng ,Li liang-ying, Yang Yang,yuan Jing-chun(1 Peking University Third Hospital (Beijing 100083); 2 Beijing Pharmaceutical Association (Beijing 100027) |
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| Abstract: | Objective Purpose When Schisandra chinensis （Turcz.） Baill and Dioscorea bulbifera L. are applied together observe the capability of lysis on biochemical and liver kidney pathology change caused by Dioscorea bulbifera L Method Compare liver biochemical index and pathology of mice in Dioscorea butbifera L. group with those in group after 60 days of dosing, Results All dose levels of group demonstrated obvious lysis and containment capabilities against elevated ALT and pathology change caused by Dioscorea bulbifera L at the corresponding dose ranges. |
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| Keywords: | Dioscorea bulbifera L Schisandra chinensis （Turcz ） Bail detoxification heptatic and renal toxicity |
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