| 细胞间黏附分子-1对恶性肿瘤影响的临床研究进展 |
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| 引用本文： | 刘陶文. 细胞间黏附分子-1对恶性肿瘤影响的临床研究进展[J]. 中华肿瘤防治杂志, 2004, 11(4): 432-435 |
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| 作者姓名： | 刘陶文 |
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| 作者单位： | 广西壮族自治区南溪山医院肿瘤血液学研究所,广西,桂林,541002 |
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| 摘 要： | 细胞间黏附分子 -1(intercellularadhesionmolecule 1,ICAM 1或CD54)是免疫球蛋白超家族成员及跨膜糖蛋白 ,也是淋巴细胞功能相关抗原 -1(LFA 1)的主要配体 ,涉及细胞分化、黏附及迁移。细胞表面ICAM 1可脱落进入血循环 ,成为可溶性形式ICAM 1(sICAM 1)。sICAM 1仍具有结合LFA 1的活性 ,sICAM 1/LFA 1介导多种病理过程。研究表明 :sICAM 1水平升高与多种恶性肿瘤患者的不良结局有关
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| 关 键 词： | 细胞间黏附分子 可溶性 肿瘤/病理学 综述文献 |
| 文章编号： | 1009-4571(2004)04-0432-04 |
| 修稿时间： | 2003-07-25 |
Update of clinical significances on intercellular adhesion molecule-1 in malignancies |
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| LIU Tao-wenInstitute of Oncol/Hematol,Nanxishan Hospital of Guangxi,Guilin ,P.R.China. Update of clinical significances on intercellular adhesion molecule-1 in malignancies[J]. Chinese Journal of Cancer Prevention and Treatment, 2004, 11(4): 432-435 |
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| Authors: | LIU Tao-wenInstitute of Oncol/Hematol Nanxishan Hospital of Guangxi Guilin P.R.China |
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| Affiliation: | LIU Tao-wenInstitute of Oncol/Hematol,Nanxishan Hospital of Guangxi,Guilin 541002,P.R.China |
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| Abstract: | Intercellular adhesion molecule-1(ICAM-1,CD 54) is a member of immunoglobulin superfamily (IGSF),a transmembrance glucoprotein,and the major ligand of lymphocyte function associated antigen-1(LFA-1),involved in differentiation,adhesion and migration of cells.The cell surface ICAM-1 could be shedded and existed in blood circulation (soluble ICAM-1,sICAM-1),which has the activity to combine LFA-1,and interfere with biological effects of ICAM-1/LFA-1.It is known the elevated concentration of sICAM-1 in solid tumors and hematopoietic malignancies impacts on the clinical outcome of these disorders. |
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| Keywords: | intercellular adhesion molecules carcinoma neoplasms/pathology review literature |
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