| 单纯疱疹病毒Ⅱ型三万道尔顿糖蛋白的纯化及其特性研究 |
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| 引用本文： | 秦克锋,汪美先,姜绍谆,马文煜. 单纯疱疹病毒Ⅱ型三万道尔顿糖蛋白的纯化及其特性研究[J]. 医学争鸣, 1985, 0(4) |
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| 作者姓名： | 秦克锋 汪美先 姜绍谆 马文煜 |
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| 作者单位： | 第四军医大学微生物学教研室(秦克锋，汪美先，姜绍谆)，第四军医大学微生物学教研室(马文煜) |
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| 摘 要： | 用抗HSV—Ⅱ型特异性单克隆抗体CH—A9与Sepharose 4B偶联制备免疫吸附柱作亲和层析,纯化出HSV—Ⅱ30,000道尔顿糖蛋白。结果表明,该糖蛋白特性与文献报道的各种HSV糖蛋白均不相同:首先,其分子量明显较小,其次,具有HSV—Ⅱ型特异性。
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| 关 键 词： | 单纯疱疹病毒 糖蛋白 单克隆抗体 亲和层析 |
A 30,000- DALTON GLYCOPROTEIN INDUCED BY HERPES SIMPLEX VIRUS TYPE 2 |
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| Qin ke-feng. A 30,000- DALTON GLYCOPROTEIN INDUCED BY HERPES SIMPLEX VIRUS TYPE 2[J]. Negative, 1985, 0(4) |
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| Authors: | Qin ke-feng |
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| Affiliation: | Department of Microbiology |
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| Abstract: | A 30,000 dalton glycoprotein (g30K) induced by herpes simplex virus type-2 (HSV-2) was purified on an immunoadsorbent column consisting of the HSV-2 type- specific monoclonal antibody (McAb) CH-A9 linked to seph-arose 4B. Evidence is presented showing that this glycopotein has properties distinct from those assigned to any other HSV glycoprotein. First, its molecular weight is lower than other HSV glycoproteins. And second, it is HSV-2 type-specific antigen. |
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| Keywords: | herpes simple virus glycoprotein monoclonal antibody chro-matography |
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