A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1 |
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| Authors: | John,Wijdenes ,Wim C.,Vooijs ,Claude,Clé ment ,Jacob,Post ,Florence,Morard ,Natalio,Vita ,Patrick,Laurent ,Ren-Xiao, Sun ,Bernard,Klein & Jean-Michel, Dore |
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| Affiliation: | Diaclone, Besançon, France;, University Hospital, Utrecht, The Netherlands;, Sanofi, Labège, France;, Institute for Molecular Genetics, Montpellier, France |
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| Abstract: | We developed a new monoclonal antibody, B-B4, which specifically identifies human plasma cells. It strongly reacts with all multiple myeloma cell lines and with malignant plasma cells of all tumour samples of the multiple myeloma patients tested. B-B4 does not react with any peripheral blood, bone marrow or tonsil cells. Cloning of the B-B4 antigen reveals that the monoclonal antibody recognizes syndecan-1. It appears that the monoclonal antibody B-B4 is a suitable marker for human plasmocyte identification among haemopoietic cells and a useful probe for the diagnosis of haematological malignancies. Furthermore, this monoclonal antibody can be used for depletions prior to CD34 grafting. |
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| Keywords: | B-B4 mAb plasmocyte syndecan-1 multiple myeloma |
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