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Potentin Vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomyceteSac-charopolyspora sp. nov. |
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| Authors: | Rui Liu Cheng-Bin Cui Lin Duan Qian-Qun Gu Wei-Ming Zhu |
| Institution: | Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China. |
| Abstract: | Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines. |
| Keywords: | Mycale plumose Sponge-derived actinomycete Saccharopolyspora sp nov Metacycloprodigiosin Undecylprodigiosin Tripyrrole pigments Cytotoxicity |
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