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| 急性髓系白血病MDR1和BAALC基因表达水平及其预后意义的探讨 | |
| 引用本文： | 刘秉珊,郭绪涛,查洁,史鹏程,黄芬,陈伟丰,徐兵.急性髓系白血病MDR1和BAALC基因表达水平及其预后意义的探讨[J].中华肿瘤防治杂志,2011,18(21). |
| 作者姓名： | 刘秉珊 郭绪涛 查洁 史鹏程 黄芬 陈伟丰 徐兵 |
| 作者单位： | 1. 南方医科大学南方医院血液科,广东广州510515;解放军第一五五中心医院血液肿瘤科,河南开封475003 2. 南方医科大学南方医院血液科,广东广州,510515 3. 汕头市中心医院血液科,广东汕头,515031 |
| 基金项目： | 广东省科技计划资助项目(2007B030704010) |
| 摘 要： | 目的:探讨联合检测初治急性髓系白血病(AML)组织多药耐药基因1(MDR1)及脑和急性白血病胞质(BAALC)的表达量以及在预后判断中的作用。方法:荧光定量PCR检测并分析160例初治AML组织MDR1和BAALC基因的表达量及其与临床疗效和预后的关系。结果:初治AML组织MDR1和BAALC基因表达水平呈正相关性,P<0.001。MDR1高表达的AML患者同低表达组相比完全缓解(CR)率低,复发率高,总生存率低,P值均<0.05;而BAALC高低表达的差异均无统计学意义。MDR1和BAALC均低表达组疗效及预后最好,均高表达组最差。MDR1和BAALC均低表达组和MDR1低表达且BAALC高表达组的CR率均显著高于均高表达组,P值分别为0.004和0.034;前2组复发率(21.6%和25.9%)也显著低于后者(56.0%),P值分别为0.006和0.029;而均低表达组总生存率(62.2%)也显著高于均高表达组(28.3%)和MDR1高表达且BAALC低表达组(38.2%),P值分别为0.002和0.048。结论:MDR1高表达对初治AML患者的预后意义高于BAALC基因,只要检测到MDR1基因的高表达,... |
| 关 键 词： | 白血病 髓系 急性 基因 MDR 预后 |
Simultaneous detection of MDR1 and BAALC gene expression in acute myeloid leukemias and its clinical implication |
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| LIUBing shan,GUO Xu-tao,ZHA Jie,SHI Peng-cheng,HUANG Fen,CHEN Wei-feng,XU Bing.Simultaneous detection of MDR1 and BAALC gene expression in acute myeloid leukemias and its clinical implication[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(21). | |
| Authors: | LIUBing shan GUO Xu-tao ZHA Jie SHI Peng-cheng HUANG Fen CHEN Wei-feng XU Bing |
| Institution: | LIU Bing-shan1,3,GUO Xu-tao1,ZHA Jie1,SHI Peng-cheng1,HUANG Fen1,CHEN Wei-feng2,XU Bing1 1.Department of Hematology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,P.R China 2.Department of Hematology,Shantou Central Hospital,Shantou 515031,P.R China 3.Department of Hematology and Oncology,No.155 Central Hospital of PLA,Kaifeng 475003,P.R China |
| Abstract: | OBJECTIVE: To simultaneous detecte MDR1 and BAALC gene expressionsl in adult patients with AML patients and investigated its prognostic implications.METHODS: The MDR1 and BAALC expressions were detected by real-time fluorescent quantitative polymerase chain reaction(RQ-PCR) in 160 adult AML patients.RESULTS: There was a correlation between the expression of MDR1 and BAALC gene expression(P<0.001)in adult AML patients.There was a significant difference of CR rate,the cumulative relapse rates and survival cur... |
| Keywords: | lymphoblastic leukemia acute genes MDR prognosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |