| 香菇多糖治疗恶性胸腔积液随机对照试验的Meta分析 |
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| 引用本文： | 冯丹,刘佳丽,许崇安.香菇多糖治疗恶性胸腔积液随机对照试验的Meta分析[J].中华肿瘤防治杂志,2011,18(20):1620-1623. |
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| 作者姓名： | 冯丹 刘佳丽 许崇安 |
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| 作者单位： | 中国医科大学附属第四医院肿瘤内科,辽宁沈阳,110032 |
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| 摘 要： | 目的:运用系统评价Meta分析的方法评价香菇多糖(LNT)单药或联合其他药物治疗恶性胸腔积液(MPE)的临床疗效及安全性。方法:应用Pubmed、Cochrane图书馆、Embase、CBM、CNKI、维普及万方数据库系统,全面收集有关LNT单药或联合其他药物治疗MPE的临床对照研究。结果:本系统评价共纳入17篇随机对照试验,共计978例患者,其中LNT组500例,顺铂组478例。Meta分析结果显示,LNT组临床有效率明显优于顺铂组(OR=3.68,95%CI=2.75～4.94;P<0.000 01);LNT组治疗后Karnofsky评分升高患者例数均显著多于顺铂组患者(OR=3.79,95%CI=2.46～5.84,P<0.000 01),其降低及稳定患者例数明显低于顺铂组患者(OR=0.41,95%CI=0.21～0.78,P=0.007;OR=0.37,95%CI=0.22～0.60,P<0.000 1);LNT组胃肠道反应和血液学毒性发生率较顺铂组明显减少(OR=0.31,95%CI=0.21～0.47,P<0.000 01;OR=0.49,95%CI=0.28～0.84,P=0.01)。结论:现有证据表明,LNT单药或联合其他药物治疗MEP的临床疗效及安全性均优于顺铂单药,可广泛应用于临床治疗晚期肿瘤恶性胸腔积液。
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| 关 键 词： | 胸腔积液 恶性 香菇多糖 随机对照试验 Meta分析 |
Lentinan for treatment of malignant pleural effusion:A meta-analysis of randomized controlled trials |
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| FENG Dan,LIU Jia-li,XU Chong-an.Lentinan for treatment of malignant pleural effusion:A meta-analysis of randomized controlled trials[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(20):1620-1623. |
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| Authors: | FENG Dan LIU Jia-li XU Chong-an |
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| Institution: | FENG Dan,LIU Jia-li,XU Chong-an Department of Oncology,Fourth Affiliated Hospital,China Medical University,Shenyang 110032,P.R.China |
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| Abstract: | OBJECTIVE:To investigate the efficacy and safety of lentinan(LNT) for the treatment of malignant pleural effusion(MPE) by conducting a meta-analysis.METHODS: Publications addressing the efficacy and safety of LNT for the treatment of MPE were selected from Pubmed,Cochrane library,Embase,CBM,CNKI,VIP and Wanfang databases.RESULTS: Seventeen studies involving 978 patients were identified,with 500 patients in LNT group and 478 patients in cisplatin group.Patients in LNT group has a better clinical response rat... |
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| Keywords: | pleural effusion malignant lentinan randomized controlled trials Meta-analysis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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