| 三氧化二砷及人参皂甙对兔肝VX2肿瘤抗血管生成作用的比较 |
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| 引用本文： | 李红,徐克. 三氧化二砷及人参皂甙对兔肝VX2肿瘤抗血管生成作用的比较[J]. 中华肿瘤防治杂志, 2011, 18(19) |
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| 作者姓名： | 李红 徐克 |
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| 作者单位： | 中国医科大学附属第一医院放射科,辽宁沈阳,110001 |
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| 基金项目： | 辽宁省科学技术基金(2010225032); 辽宁省教育厅资助项目(L2010603) |
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| 摘 要： | 目的:比较三氧化二砷(As2O3)及人参皂甙(Rg3)对兔肝VX2肿瘤血管生成的作用。方法:复制兔肝VX2肿瘤模型24只,随机分为As2O3组、Rg3组及空白对照组各8只,As2O3组连续1周耳缘静脉注射用药,Rg3组连续1周灌服参一胶囊,空白对照组仅给予药物载体溶质作为对照。测量肿瘤瘤质量,应用免疫组化检测瘤组织中的微血管密度(MVD)及血管内皮生长因子(VEGF)的表达。并采静脉血检测肝功能。结果:As2O3组和Rg3组肿瘤瘤质量显著低于对照组,P值分别为0.013和0.033;As2O3组及Rg3组的MVD表达明显低于对照组,P值分别为0.006和0.003;VEGF表达也明显低于对照组,P值分别为0.049和0.021。As2O3组及Rg3组MVD及VEGF比较差异无统计学意义,P>0.05。结论:As2O3及Rg3均可抑制兔肝VX2肿瘤生长,对肿瘤血管生成具有抑制作用,两者对肿瘤血管的抑制作用无差异。
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| 关 键 词： | 肝肿瘤 实验性 砷剂 人参皂甙 VX2肿瘤 新生血管化 病理性 |
Comparison of inhibiting angiogenesis between As_2O_3 and Rg3 in rabbit liver VX2 tumor |
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| LI Hong,XU Ke. Comparison of inhibiting angiogenesis between As_2O_3 and Rg3 in rabbit liver VX2 tumor[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(19) |
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| Authors: | LI Hong XU Ke |
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| Affiliation: | LI Hong,XU Ke Department of Radiology,Affiliated First Hospital of China Medical University,Shenyang 110001,P.R.China |
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| Abstract: | OBJECTIVE: To compare As2O3 with Ginsenoside Rg3 in the effect of inhibiting angiogenesis in VX2 transpled hepatic tumor model in experimental rabbits.METHODS: Twenty-four liver VX2 tumor models of rabbits were divided into 3 groups randomly and equally(with 8 in each group),As2O3 group(treated with As2O3 intravenously for one week),Ginsenoside group(treated with Shenyi capsule by oral administration for one week),control group(without treatment).Tumor micro-vessel density(MVD) and the expression of vascula... |
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| Keywords: | liver neoplasms experimental arsenicals ginsenoside VX2 tumor neovascularization pathologic |
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