| Y染色体微缺失及其检测方法 |
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| 引用本文： | 高云,陈嘉昌,彭焕玉,朱振宇. Y染色体微缺失及其检测方法[J]. 分子诊断与治疗杂志, 2011, 3(5): 326-329 |
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| 作者姓名： | 高云 陈嘉昌 彭焕玉 朱振宇 |
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| 作者单位： | 1. 中山大学中山医学院,广东,广州510080
2. 中山大学达安基因诊断中心,广东,广州510665 |
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| 基金项目： | 国家高技术研究发展计划(863计划)，广州开发区经济发展和技术局项目 |
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| 摘 要： | 全世界大约有15％的夫妇不育,其中男性不育约占50％.Y染色体长臂上的AZF缺失是导致男性不育的重要因素.AZF进一步分为AZFa、AZFb和AZFc 3个区域,不同区域的微缺失引起不同程度的精子发生障碍.因此Y染色体微缺失的检测对男性不育的诊治有很重要的指导意义.目前Y染色体微缺失常用的检测方法有多重定性PCR法、实...
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| 关 键 词： | Y染色体微缺失 男性不育 AZF |
Y chromosome microdeletions and the detection methods |
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| GAO Yun,CHEN Jiachang,PENG Huanyu,ZHU Zhenyu. Y chromosome microdeletions and the detection methods[J]. Journal of Molecular Diagnosis and Therapy, 2011, 3(5): 326-329 |
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| Authors: | GAO Yun CHEN Jiachang PENG Huanyu ZHU Zhenyu |
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| Affiliation: | 1.Zhongshan School of Medicine,Sun Yat-sen University,Guangdong,Guangzhou 510080,China;2.Daan Gene Diagnostic Center of Sun Yat-sen University,Guangdong,Guangzhou 510665,China) |
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| Abstract: | There are many cases of infertility,which affects approximately 15% of all married couples attempting pregnancy in the general population,and the male factor is responsible for approximately 50% of the cases.Azoospermia factor （AZF） microdeletions in Y chromosome are an important cause of spermatogenetic failure in infertile men.AZF is divided into three regions （AZFa,AZFb and AZFc）.Different deletions can lead to different levels of spermatogenesis.The detection of Y chromosome microdeletions has important instructional significance to the treatment of male infertility.At present,the usual detection methods of Y chromosome microdeletions include multiplex qualitative PCR,real-time fluorescence,gene chip,fluorescence in situ hybridization and so on. |
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| Keywords: | Y chromosome microdeletion Male infertility AZF |
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