| 乳腺癌组织瘦素与凋亡调节因子表达相关性的研究 |
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| 引用本文： | 夏想厚,谷俊朝,杜松涛,薛荣泉. 乳腺癌组织瘦素与凋亡调节因子表达相关性的研究[J]. 中华肿瘤防治杂志, 2011, 18(20) |
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| 作者姓名： | 夏想厚 谷俊朝 杜松涛 薛荣泉 |
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| 作者单位： | 首都医科大学附属北京友谊医院普外科,北京,100050 |
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| 基金项目： | 首都医学科学发展基金(2005-2031) |
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| 摘 要： | 目的:探讨在乳腺癌病理组织中瘦素表达与凋亡调节因子Survivin、Bcl-2和BAX表达的相关性。方法:选取首都医科大学附属北京友谊医院普外科2003-01-2005-01,接受手术切除的102例乳腺癌患者的组织标本蜡块,免疫组织化学方法测定组织中Leptin和Sur-vivin、Bcl-2、BAX的表达。统计分析leptin与Survivin、Bcl-2、BAX在乳腺癌组织中表达的相关性,以及它们与乳腺癌临床病理特征的相关性。结果:瘦素在乳腺癌中表达与肿瘤大小(r=0.246,P=0.013)、淋巴结转移(r=0.209,P=0.035)和远处转移(r=0.215,P=0.030)呈正相关;Survivin在乳腺癌组织中表达与肿瘤大小(r=0.313,P=0.001)、远处转移(r=0.204,P=0.040)呈正相关;Bcl-2在乳腺癌组织中表达与肿瘤大小(r=0.246,P=0.013)、淋巴结转移(r=0.287,P=0.003)呈正相关。瘦素与Survivin(r=0.247,P=0.012)、Bcl-2(r=0.230,P=0.020)在乳腺癌组织中表达呈正相关。结论:在乳腺癌组织中,瘦素的表达...
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| 关 键 词： | 乳腺肿瘤 瘦素 细胞凋亡 免疫组织化学 |
Coexpression of Leptin and apotosis modulators in breast cancer tissues |
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| XIA Xiang-hou,GU Jun-chao,DU Song-tao,XUE Rong-quan. Coexpression of Leptin and apotosis modulators in breast cancer tissues[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(20) |
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| Authors: | XIA Xiang-hou GU Jun-chao DU Song-tao XUE Rong-quan |
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| Affiliation: | XIA Xiang-hou,GU Jun-chao,DU Song-tao,XUE Rong-quan Department of General Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,P.R.China |
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| Abstract: | OBJECTIVE:To detect the correlation between leptin,Survivn,Bcl-2 and BAX expression profiles and clinicopathological features in breast cancer tissues.METHODS: Immunohistochemistry(IHC) was performed on paraffin-embedded tissue microarray containing specimens from 102 breast cancer patients hospitalized in Beijing Friendship hospital affiliated Capital Medical University from January,2003 to January,2005.The intensity and the extent of IHC were scored by pathologists blind to clinicopathological features of... |
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| Keywords: | breast neoplasms leptin apoptosis Immunohistochemistry |
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