Rituximab for plasma exchange-dependent recurrent focal segmental glomerulosclerosis after renal transplantation |
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| Authors: | Deegens Jeroen K J; Wetzels Jack F M |
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| Institution: | Department of Nephrology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands |
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| Abstract: | |
Introduction
| Focal segmental glomerulosclerosis (FSGS) can recur after renaltransplantation and is associated with a reduced graft survival.In the case of recurrent FSGS, treatment with plasma exchange(PE) results in a remission of proteinuria in up to 85% of patients,especially if started shortly after the onset of recurrence1,2]. However, many patients require repeated courses of PEbecause of frequent relapses 1,3]. Recently, a 7-year-old boywith recurrent FSGS after renal transplantation responded torituximab, a monoclonal anti-CD20 antibody, that was administeredfor a transplantation-related lymphoma 4]. Following this report,several other cases with recurrent FSGS after renal transplantationwere published, showing varying degrees of success after treatmentwith rituximab 5]. We describe
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| Keywords: | focal segmental glomerulosclerosis recurrence renal transplantation rituximab |
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