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The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders |
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| Authors: | Graham Cocks Sarah Curran Priya Gami Dafe Uwanogho Aaron R. Jeffries Annie Kathuria Walter Lucchesi Victoria Wood Rosemary Dixon Caroline Ogilvie Thomas Steckler Jack Price |
| Affiliation: | 1. Department of Neuroscience, The James Black Centre, King’s College London, 125 Coldharbour lane, London, UK 2. Child and Adolescent Psychiatry Department and MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK 3. Guy’s and St. Thomas’ Centre for Pre-implantation Genetic Diagnosis and Genetics Centre, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK 4. Neuroscience Discovery, Janssen Research and Development, Beerse, Belgium |
| Abstract: | Until now, models of psychiatric diseases have typically been animal models. Whether they were to be used to further understand the pathophysiology of the disorder, or as drug discovery tools, animal models have been the choice of preference in mimicking psychiatric disorders in an experimental setting. While there have been cellular models, they have generally been lacking in validity. This situation is changing with the advent of patient-specific induced pluripotent stem cells (iPSCs). In this article, we give a methodological evaluation of the current state of the iPS technology with reference to our own work in generating patient-specific iPSCs for the study of autistic spectrum disorder (ASD). In addition, we will give a broader perspective on the validity of this technology and to what extent it can be expected to complement animal models of ASD in the coming years. |
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