| 特应性皮炎瘙痒机制的研究进展 |
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| 引用本文： | 王傲 姚煦. 特应性皮炎瘙痒机制的研究进展[J]. 中华皮肤科杂志, 2022, 55(4): 357-361. DOI: 10.35541/cjd.20201117 |
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| 作者姓名： | 王傲 姚煦 |
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| 作者单位： | 中国医学科学院、北京协和医学院皮肤病医院过敏与风湿免疫科,南京210042 |
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| 基金项目： | 国家自然科学基金(82073446); |
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| 摘 要： | 【摘要】 特应性皮炎（AD）瘙痒是一种典型的非组胺相关瘙痒,涉及复杂的神经传导通路。多种细胞因子和神经肽类物质以及皮肤屏障功能障碍、皮肤菌群失调也参与瘙痒信号的产生和传递。本综述聚焦近年AD瘙痒发病机制和治疗的主要研究进展。
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| 关 键 词： | 皮炎 特应性 瘙痒症 细胞因子类 皮肤屏障 皮肤菌群 |
| 收稿时间： | 2020-11-20 |
Mechanisms of pruritus in atopic dermatitis |
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| Wang Ao,Yao Xu. Mechanisms of pruritus in atopic dermatitis[J]. Chinese Journal of Dermatology, 2022, 55(4): 357-361. DOI: 10.35541/cjd.20201117 |
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| Authors: | Wang Ao Yao Xu |
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| Affiliation: | Department of Allergy and Rheumatology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China |
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| Abstract: | 【Abstract】 Pruritus in atopic dermatitis （AD） is a typical non-histaminergic itch involving complex nerve pathways. A variety of cytokines and neuropeptides, skin barrier dysfunction and skin microbiome imbalance are also involved in the generation and transmission of itching-relatd signals. This review focuses on main research progress in the pathogenesis and treatment of pruritus in AD in recent years. |
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| Keywords: | Dermatitis atopic Pruritus Cytokines Skin barrier Skin microbiome |
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