阿司匹林肠溶片联合盐酸拉贝洛尔治疗妊娠期高血压的临床疗效及安全性

目的分析阿司匹林肠溶片联合盐酸拉贝洛尔治疗妊娠期高血压的临床疗效及安全性。方法90例妊娠期高血压患者,采取随机数字表法分为对照组与观察组,各45例。对照组给予盐酸拉贝洛尔溶液治疗,观察组在对照组基础上加用阿司匹林肠溶片治疗。对比两组治疗前后血压水平、不良妊娠结局及不良反应发生情况。结果治疗前,两组收缩压和舒张压对比,差异无统计学意义(P>0.05);治疗后,两组收缩压及舒张压均低于治疗前,且观察组收缩压(125.44±5.21)mm Hg(1 mm Hg=0.133 kPa)和舒张压(84.10±2.77)mm Hg低于对照组的(145.98±6.10)、(98.98±3.88)mm Hg,差异有统计学意义(P<0.05)。观察组剖宫产、早产、胎儿窘迫发生率分别为26.67%、6.67%、4.44%,均低于对照组的46.67%、22.22%、20.00%,差异有统计学意义(P<0.05);两组产后出血、新生儿窒息及新生儿死亡发生率对比,差异无统计学意义(P>0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论阿司匹林肠溶片联合盐酸拉贝洛尔治疗妊娠期高血压可有效控制血压,降低不良妊娠结局发生率,且治疗期间未增加不良反应,安全性较高。

Clinical efficacy and safety of aspirin enteric-coated tablets combined with labetalol hydrochloride in the treatment of hypertension during pregnancy

Objective To analyze the clinical efficacy and safety of aspirin enteric-coated tablets combined with labetalol hydrochloride in the treatment of hypertension during pregnancy.Methods A total of 90 patients with hypertension during pregnancy were divided into control group and observation group by random numerical table,with 45 cases in each group.The control group was treated with labetalol hydrochloride solution,and the observation group was treated with aspirin enteric-coated tablets on the basis of the control group.The blood pressure levels before and after treatment,adverse pregnancy outcomes and occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in systolic blood pressure and diastolic blood pressure between the two groups(P>0.05).After treatment,the systolic blood pressure and diastolic blood pressure of the two groups were lower than those of this group before treatment;the systolic blood pressure(125.44±5.21)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure(84.10±2.77)mm Hg of the observation group were lower than(145.98±6.10)and(98.98±3.88)mm Hg of the control group;all the differences were statistically significant(P<0.05).The incidence of cesarean section,premature delivery,and fetal distress in the observation group were 26.67%,6.67%,and 4.44%,which were lower than 46.67%,22.22%,and 20.00%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of postpartum hemorrhage,neonatal asphyxia and neonatal death between the two groups(P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Aspirin enteric-coated tablets in combination with labetalol hydrochloride in the treatment of hypertension during pregnancy can effectively control blood pressure and reduce the incidence of adverse pregnancy outcomes.There is no increase in adverse reactions during the treatment,and the safety is high.