| PI3K/AKT/mTOR信号通路参与脊髓损伤后神经元自噬的研究进展 |
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| 引用本文： | 孙瑞欣,赵帅帅,申宇哲,梁家兴,杨彦玲.PI3K/AKT/mTOR信号通路参与脊髓损伤后神经元自噬的研究进展[J].天津医药,2022,50(4):439-443. |
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| 作者姓名： | 孙瑞欣 赵帅帅 申宇哲 梁家兴 杨彦玲 |
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| 作者单位： | 1延安大学医学院（邮编716000）；2延安市神经科学重点实验室 |
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| 基金项目： | 国家自然科学基金资助项目（81760235）；;陕西省科技厅项目社发公关项目（2019SF-041）； |
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| 摘 要： | PI3K/AKT/mTOR信号通路是脊髓损伤后的一条经典的自噬途径，脊髓损伤后导致的神经元细胞凋亡、轴
突脱髓鞘和炎症反应等受 PI3K/AKT/mTOR 信号通路的调控，并和神经元自噬相关。介绍脊髓损伤后 PI3K/AKT/
mTOR信号通路在神经元自噬过程中的主要作用，为进一步研究脊髓损伤提供参考。
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| 关 键 词： | 脊髓损伤 自噬 PI3K/AKT/mTOR信号通路 |
| 收稿时间： | 2021-09-08 |
| 修稿时间： | 2021-12-21 |
Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after
spinal cord injury |
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| SUN Ruixin,ZHAO Shuaishuai,SHEN Yuzhe,LIANG Jiaxing,YANG Yanling.Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after
spinal cord injury[J].Tianjin Medical Journal,2022,50(4):439-443. |
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| Authors: | SUN Ruixin ZHAO Shuaishuai SHEN Yuzhe LIANG Jiaxing YANG Yanling |
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| Institution: | 1 School of Medicine, Yan'an University, Yan'an 716000, China; 2 Yan'an Key Laboratory of Neuroscience
△Corresponding Author and Revisor E-mail: yangyanling8889@163.com |
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| Abstract: | PI3K/AKT/mTOR signaling pathway is a classic autophagy pathway after spinal cord injury. Neuronal
apoptosis, axon demyelination and inflammatory response after spinal cord injury are regulated by PI3K/AKT/mTOR
signaling pathway, and are related to neuronal autophagy. This paper introduces the main role of PI3K/AKT/mTOR signaling
pathway and neuronal autophagy response after spinal cord injury, hoping to provide reference for further research on spinal
cord injury. |
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| Keywords: | spinal cord injury autophagy PI3K/AKT/mTOR signaling pathway |
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