Prefrontal White Matter Abnormalities Associated With Pain Catastrophizing in Patients With Complex Regional Pain Syndrome |
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| Authors: | Jooyeon Jamie Im Jungyoon Kim Hyeonseok Jeong Jin Kyoung Oh Suji Lee In Kyoon Lyoo Yong-An Chung Sujung Yoon |
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| Affiliation: | 1. Department of Radiology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea;2. Ewha Brain Institute, Ewha W. University, Seoul, South Korea;3. Department of Brain and Cognitive Sciences, Ewha W. University, Seoul, South Korea;4. Graduate School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea;5. Department of Psychiatry, University of Utah, Salt Lake City, Utah |
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| Abstract: | ObjectiveTo investigate altered prefrontal white matter integrity in complex regional pain syndrome (CRPS) and its relation with the degree of pain catastrophizing.DesignCross-sectional study.SettingUniversity hospital.ParticipantsTwenty-one CRPS patients and 49 patients without CRPS (N=70).InterventionsNot applicable.Main Outcome MeasuresThe fractional anisotropy values within the prefrontal regions reflecting the structural integrity of white matter were measured in CRPS patients and patients without CRPS using diffusion tensor imaging. The degree of pain catastrophizing was also evaluated in CRPS patients.ResultsThe structural integrity of the prefrontal white matter was lower in CRPS patients than in patients without CRPS (P=.03). In addition, lower structural integrity in the prefrontal cortex was correlated with a higher degree of pain catastrophizing among CRPS patients (r= ?0.54, P=.01).ConclusionsOur findings suggest that pain catastrophizing, which is frequently reported in patients with CRPS, may be associated with the dysfunction of the prefrontal white matter. |
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| Keywords: | Catastrophizing Complex regional pain syndrome Diffusion tensor imaging Prefrontal cortex Rehabilitation White matter BA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" Brodmann area CRPS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" complex regional pain syndrome DTI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" diffusion tensor imaging FA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" fractional anisotropy MD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" mean diffusivity MRI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" magnetic resonance imaging PCS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" Pain Catastrophizing Scale PFC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" prefrontal cortex RD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" radial diffusivity ROI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" region of interest SF-MPQ" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," _" :" short-form McGill Pain Questionnaire VAS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" visual analog scale |
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