极高水平高密度脂蛋白胆固醇患者的临床特征分析

目的 在高密度脂蛋白胆固醇(HDL-C)水平极度升高会增加心血管死亡的背景下,分析具有HDL-C极高水平的心血管患者的临床特征,为探索HDL-C与心血管疾病的关系及进一步知晓HDL的代谢机制提供依据.方法 回顾分析2019年全年在中国医科大学附属第一医院心血管内科就诊并行血脂检测的成年患者信息.将HDL-C ≥2.59...

Clinical characteristics of patients with extremely high level of high-density lipoprotein cholesterol

Objective Extremely high level of high-density lipoprotein cholesterol(HDL-C)has been proven to increase cardiovascular mortality.This study aimed to investigate clinical characteristics of cardiovascular patients with extremely high level of HDL-C,providing information for further research concerning the relationship between HDL-C and cardiovascular diseases,as well as mechanisms of HDL metabolism.Methods All adult blood-lipid data in the Department of Cardiology in the First Hospital of China Medical University throughout the entire year of 2019 were retrospectively analysed.Extremely high level of HDL-C was defined as HDL-C≥2.59 mmol/L(100 mg/dL).Gender,age,and medical information of each patient were evaluated.Their lipid profiles were compared with healthy individuals who underwent a checkup in the same hospital during the same period with matched gender and age.Results A total of 20655 patients were included in the final analysis,and patients with an extremely high level of HDL-C covered only 0.16%;they were primarily females and outpatients.Their average age was(60.21±10.27)years,higher than those with normal HDL-C.Their average total cholesterol(TC)level,triglyceride(TG)level,low-density lipoprotein cholesterol(LDL-C)level,and non-high-density lipoprotein cholesterol(non HDL-C)were(6.22±0.95)mmol/L,(0.82±0.36)mmol/L,(3.05±0.75)mmol/L,and(3.30±0.80)mmol/L,respectively.Compared with matched healthy individuals,they had elevated TC and HDL-C/TC ratio(P<0.001),reduced TG(P<0.001),and comparable LDL-C(P=0.756)and non HDL-C(P=0.058),irrespective of gender.Conclusion Patients with extremely high HDL-C are primarily females and outpatients with elder age.Compared with matched healthy individuals,they have reduced TG and comparable LDL-C and non-HDL-C,probably indicating irrelevance between increased cardiovascular risks and LDL-C,TG,and apolipoprotein B.