| 玫瑰痤疮神经源性炎症及肉毒毒素治疗相关机制的研究进展 |
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| 引用本文： | 刘乙萱,姜沛彧,刘韵祎,张嘉文,陶梦,李敏,许阳.玫瑰痤疮神经源性炎症及肉毒毒素治疗相关机制的研究进展[J].中华皮肤科杂志,2022,55(6):552-554. |
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| 作者姓名： | 刘乙萱 姜沛彧 刘韵祎 张嘉文 陶梦 李敏 许阳 |
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| 作者单位： | 南京医科大学第一附属医院皮肤科，南京210029 |
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| 基金项目： | 国家自然科学基金(81301384)； |
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| 摘 要： | 【摘要】 局部血管神经功能失调是玫瑰痤疮发病的重要因素，已证实神经源性炎症是神经血管失调的重要环节，而皮内注射肉毒毒素可缓解面部潮红、灼热表现，可能与抑制神经末梢神经肽释放以及抑制肥大细胞脱颗粒有关。本文综述玫瑰痤疮发病机制中神经源性炎症以及肉毒毒素治疗玫瑰痤疮的相关研究进展，以期为玫瑰痤疮神经相关基础研究及临床治疗提供依据。
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| 关 键 词： | 红斑痤疮 神经原性感染 内毒毒素类 |
| 收稿时间： | 2020-03-17 |
Mechanism of neurogenic inflammation and botulinum toxin treatment in rosacea |
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| Liu Yixuan,Jiang Peiyu,Liu Yunyi,Zhang Jiawen,Tao Meng,Li Min,Xu Yang.Mechanism of neurogenic inflammation and botulinum toxin treatment in rosacea[J].Chinese Journal of Dermatology,2022,55(6):552-554. |
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| Authors: | Liu Yixuan Jiang Peiyu Liu Yunyi Zhang Jiawen Tao Meng Li Min Xu Yang |
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| Institution: | Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China |
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| Abstract: | 【Abstract】 Localized neurovascular dysregulation is an important factor for the occurrence of rosacea, and it has been confirmed that neurogenic inflammation is a key step in neurovascular dysregulation. Intradermal injection of botulinum toxin can relieve facial flushing and burning sensations, which may be attributed to the inhibition of neuropeptide release from nerve endings and degranulation of mast cells. This review summarizes the research progress in neurogenic inflammation in the pathogenesis of rosacea and botulinum toxin in the treatment of rosacea, aiming to provide a basis for nerve-related basic research and clinical treatment of rosacea. |
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| Keywords: | Rosacea Neurogenic inflammation Botulinum toxins |
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