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High Frequency and Intensity Rehabilitation in 641 Subacute Ischemic Stroke Patients
Authors:József Tollár  Ferenc Nagy  Bence Csutorás  Nándor Prontvai  Zsófia Nagy  Katalin Török  Eszter Blényesi  Zsolt Vajda  Dóra Farkas  Béla E. Tóth  Imre Repa  Mariann Moizs  Dávid Sipos  András Kedves  Árpád Kovács  Tibor Hortobágyi
Affiliation:1. Somogy County Móricz Kaposi Teaching Hospital, Kaposvár, Hungary;2. University of Pécs, Faculty of Health Sciences, Doctoral School of Health Sciences, Pécs, Hungary;3. Dr József Baka Diagnostical, Oncoradiological, Research and Educational Center, Kaposvár, Hungary;4. Department of Pharmaceutical Surveillance and Economics, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary;5. Department of Oncoradiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;6. University of Groningen, University Medical Center, Groningen, The Netherlands
Abstract:ObjectivesTo determine the effects of exergaming on quality of life (QoL), motor, and clinical symptoms in subacute stroke patients.DesignA pseudorandomized controlled trial, using a before-after test design.SettingUniversity hospital.ParticipantsSubacute, ischemic stroke outpatients (N=3857), 680 of whom were randomized and 641 completed the study.InterventionsWe determined the effects of 5 times a week twice daily (EX2; 50 sessions; n=286) and once daily (EX1; 25 sessions; n=272) exergaming and low-intensity standard care (control [CON]; 25 sessions; n=83) on clinical, mobility, blood pressure (BP), and QoL outcomes.Main Outcome MeasuresThe primary outcome was Modified Rankin Scale. Secondary outcomes were activities of daily living, 5 aspects of health-related QoL, Beck Depression Inventory, 6-minute walk test (6MWT), Berg Balance Scale (BBS), and static balance (center of pressure).ResultsDuring exercise, the peak heart rate was 134, 134, and 126 beats per minute in the EX2, EX1, and CON groups, respectively. mRS improved similarly in the EX2 (–1.8; effect size, d=–4.0) and EX1 (–1.4; d=–2.6) groups, but more than in the CON group (–0.7; d=–0.6). QoL, Barthel Index, BBS, 6MWT, and standing posturography improved more in the EX2 group and the same in the EX1 and CON groups. Systolic and diastolic resting BP decreased more in the EX2 and EX1 groups than in the CON group. The intervention effects did not differ between men (n=349) and women (n=292).ConclusionsTwice daily compared with once daily high-intensity exergaming or once daily lower intensity standard care produced superior effects on clinical and motor symptoms, BP, and QoL in male and female subacute ischemic stroke participants.
Keywords:Activities of daily living  Exercise  Quality of life  Rehabilitation  Virtual reality  6MWT"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  6-minute walk test  ADL"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0050"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  activities of daily living  BBS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0060"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Berg Balance Scale  BI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0070"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Barthel Index  BP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0080"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  blood pressure  CON"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0090"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  control group  COP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0100"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  center of pressure  EQ5-VAS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0110"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  100 mm visual analog measure of health-related quality of life  EX1"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0120"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  1 exergaming session daily  EX2"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0130"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  2 exergaming sessions daily  HR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0140"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  heart rate  mRS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0150"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  modified Rankin Scale  PD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0160"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Parkinson disease  PwS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0170"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  people with stroke  partial eta squared  QoL"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0190"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  quality of life  rBP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0200"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  resting blood pressure  rHR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0210"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  resting heart rate  RPE"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0220"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  rate of perceived exertion  rSBP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0230"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  resting systolic blood pressure
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