Anxiolytic-like action of melatonin on acquisition but not performance of DRL |
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| Authors: | K Neville N McNaughton |
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| Affiliation: | 1. Department of Energy Systems and Environment, Ecole des Mines de Nantes, GEPEA, CNRS, UMR 6144, Nantes, France;2. Veolia Recherche et Innovation (VERI), Limay, France;3. Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands;1. Department of Food Chemistry and Technology, Teagasc Food Research Centre, Ashtown, Dublin, D15KN3K, Ireland;2. School of Biosystems and Food Engineering, University College Dublin, Ireland;1. School of Geomatics and Urban Spatial Informatics, Beijing University of Civil Engineering and Architecture, No. 1, Zhanlanguan Road, Xicheng District, Beijing, 100044, China;2. The Key Laboratory for Urban Geomatics of National Administration of Surveying, Mapping and Geoinformation, Beijing University of Civil Engineering and Architecture, Beijing, 100044, China;1. College of Civil Engineering, Nanjing Forestry University, Nanjing 210037, China;2. College of Material Science and Engineering, Southwest Forestry University, Kunming 650224, China;1. SKKU Advanced Institute of Nanotechnology, Sungkyunkwan University, Suwon 440-746, South Korea;2. Center for Electronic Materials, Post-Silicon Semiconductor Institute, Korea Institute of Science and Technology, Seoul 136-791, South Korea |
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| Abstract: | The behavioural effects of melatonin have been attributed to a general reduction in motor activity; interference with memory fixation; a decrease in emotionality; or an anxiolytic action. The present experiments compared the effects of melatonin with an anxiolytic benzodiazepine, chlordiazepoxide (Librium), on a schedule of differential reinforcement of low rates of response (DRL) increasing 'burst' responding and premature responding. No doses of melatonin tested (0.03-8.1 mg/kg, IP) affected performance of well-learned DRL. Both low (0.03 mg/kg) and high (1.0 mg/kg) doses of melatonin impaired acquisition of DRL in a similar manner to chlordiazepoxide (5.0 mg/kg) and to much the same extent. Chlordiazepoxide had its usual effects on both acquisition and performance of DRL. These results show that melatonin shares a subset of the effects of chlordiazepoxide. The nature of the effects favours an 'anxiolytic' hypothesis of melatonin action rather than the other hypotheses so far proposed. |
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