班布特罗对豚鼠实验性哮喘的作用及其机理研究

目的 研究班布特罗对豚鼠实验性哮喘的作用、药效学及药动学特点及作用机制。方法 组胺和卵清蛋白诱发在体豚鼠实验性哮喘模型，使用豚鼠离体气管片和肺条进行研究。结果 班布特罗剂量依赖性抑制组胺和卵清蛋白诱发的豚鼠哮喘，班布特罗对豚鼠气管片无松弛作用，而灌服其后的松弛气管片和肺条血浆呈剂量依赖性，且对肺条的松弛作用强于气管片。其峰效应出现于给药后4h前后，作用持续24h以上。结论 班布特罗作为特布他林的前药对豚鼠实验性哮喘的作用缓和而持久。

Effect of bambuterol on experimental asthma and its mechanism in guinea pigs

Aim To probe the effect of bambuterol on experimental asthma and its pharmacodynamic and pharmacokinetic chracteristics,as well as its mechanism. Methods Experimental asthma model on guinea pigs was induced by histamine and ovalbumin in vivo and their trachea flake and pulmonary bar were emptied to the research in vitro respectively. Results Bambuterol inhibited asthma induced by histamine and ovalbumin in guinea pigs in a dose-dependent manner. Bambuterol gave no relaxation to all trachea flake,but the intragastric gavage(ig) of plasma of the bambuterol-treated guinea pigs relaxed trachea flake and pulmonary bar,and the effect on pulmonary bar was stronger than that on trachea flake. The peak value appeared about 4 h after administration,and the action continued for more than 24 h. Conclusion Bambuterol as pro-drug of terbutaline metabolized in body has a mild and permanent effect on the model of experimental asthma in guinea pigs.